HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: KKCC2 (Q96RR4)
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
Gene: CAMKK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 588
+	Hs
		682173 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT2_HUMAN (27-515): 1.79e-133: 399: 21.21
+	Hs
		1035058 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT3_HUMAN (107-520): 2e-132: 397: 22.86
+	Hs
		681830 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT1_HUMAN (83-515): 8.15e-132: 395: 22.27
+	Hs
		969070 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		KPCE_HUMAN (64-492): 8.86e-126: 388: 21.04
+	Rn
		193486 STIP1_RAT (265-457): 1.25e-22: 102: 18.14		AKT3_RAT (107-520): 8.99e-131: 392: 22.86