HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 389
+	Mm
		403466 GAB1_MOUSE (1-694): 0: 544: 89.93		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Hs
		548703 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV_HUMAN (6-256): 4.43e-48: 176: 15.77
+	Hs
		522965 GAB1_HUMAN (1-694): 0: 547: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		433750 GAB1_HUMAN (1-694): 0: 547: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		855792 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV2_HUMAN (6-258): 3.29e-46: 171: 13.22
+	Hs
		802837 GAB1_HUMAN (1-694): 0: 547: 100.00		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		924547 GAB1_HUMAN (1-694): 0: 547: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433345 GAB1_HUMAN (1-694): 0: 547: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Mm
		1141170 GAB1_MOUSE (1-694): 0: 544: 89.93		GRB2_MOUSE (56-256): 2.26e-50: 170: 15.71
+	Hs
		442825 GAB1_HUMAN (1-694): 0: 547: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		411709 GAB1_HUMAN (1-694): 0: 547: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Mm
		292690 GAB1_MOUSE (1-694): 0: 544: 89.93		GRAP2_MOUSE (68-234): 7.12e-47: 164: 20.11
+	Hs
		802588 GAB1_HUMAN (1-694): 0: 547: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		275195 GAB1_HUMAN (1-694): 0: 547: 100.00		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66
+	Hs
		1035397 GAB1_HUMAN (1-694): 0: 547: 100.00		HSH2D_HUMAN (76-257): 5.81e-43: 154: 31.32
+	Hs
		1035373 GAB1_HUMAN (1-694): 0: 547: 100.00		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93
+	Mm
		1246955 GAB1_MOUSE (1-694): 0: 544: 89.93		Q8R5B8_MOUSE (94-177): 4.7e-29: 110: 29.41
+	Hs
		796565 GAB1_HUMAN (1-694): 0: 547: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Hs
		434086 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		275242 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66