Protein: ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC 1.2.4.1) (Pyruvate dehydrogenase complex component E1 alpha) (PDHE1-A)

Gene: ODPA, PDA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 200
UniProt ID: P16387

Gene Ontology (top 5):
GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005739 - mitochondrion
GO:0006086 - pyruvate decarboxylation to acetyl-CoA
GO:0007124 - pseudohyphal growth
GO:0042645 - mitochondrial nucleoid

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554874

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

5

13

High-throughput

0.919

High

594912

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

4

16

High-throughput

0.892

High

594891

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

4

1

Small-scale

0.689

High

594916

PREP
Presequence protease, mitochondrial

3

12

High-throughput

0.662

High

594873

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

13

High-throughput

0.618

High

594877

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

12

High-throughput

0.618

High

394023

EFTU
Elongation factor Tu, mitochondrial

2

3

High-throughput

0.584

High

484712

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

6

High-throughput

0.584

High

510153

HSP77
Import motor subunit, mitochondrial

2

4

High-throughput

0.584

High

594871

MDHM
Malate dehydrogenase, mitochondrial

2

5

High-throughput

0.584

High

594965

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

594904

HS104
Heat shock protein 104

3

4

High-throughput

0.578

High

594875

HSP60
Heat shock protein 60, mitochondrial

2

6

High-throughput

0.571

High

594925

MDJ1
DnaJ homolog 1, mitochondrial

2

3

High-throughput

0.571

High

594906

IMB3
Importin subunit beta-3

2

1

High-throughput

0.567

High

594979

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

594956

PDK1
[Pyruvate dehydrogenase

1

9

Small-scale

0.515

High

594905

TPS2
Trehalose-phosphatase

1

0

High-throughput

0.513

High

594907

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

2

High-throughput

0.500

High

464541

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.489

High

594961

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.489

High

475104

CYAA
Adenylate cyclase

1

0

High-throughput

0.479

High

594894

FEN1
Flap endonuclease 1

1

0

High-throughput

0.479

High

594897

YJU2
Splicing factor YJU2

1

0

High-throughput

0.479

High

594985

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.479

High

366910

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.479

High

368126

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.479

High

452802

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

482180

ATPO
ATP synthase subunit 5, mitochondrial

1

2

High-throughput

0.479

High

522340

MPPB
Mitochondrial-processing peptidase subunit beta

1

11

High-throughput

0.479

High

531533

RT02
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.479

High

549930

MPPA
Mitochondrial-processing peptidase subunit alpha

1

9

High-throughput

0.479

High

578776

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

581806

SYDM
Aspartate--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

594870

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

14

High-throughput

0.479

High

594874

ACON
Aconitate hydratase, mitochondrial

1

5

High-throughput

0.479

High

594878

RT28
Small ribosomal subunit protein uS15m

1

1

High-throughput

0.479

High

594879

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

594881

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

594882

TOM40
Mitochondrial import receptor subunit TOM40

1

1

High-throughput

0.479

High

594884

SYNM
Asparagine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

594885

PRTD
Saccharolysin

1

2

High-throughput

0.479

High

594886

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.479

High

594892

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

1

High-throughput

0.479

High

594893

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

5

High-throughput

0.479

High

594895

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

594896

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

4

High-throughput

0.479

High

594900

HIBCH
Small ribosomal subunit protein mS47

1

6

High-throughput

0.479

High

594902

RF1M
Peptide chain release factor 1, mitochondrial

1

8

High-throughput

0.479

High

594903

RM09
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.479

High

594914

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

3

High-throughput

0.479

High

594917

RT04
Small ribosomal subunit protein uS2m

1

2

High-throughput

0.479

High

594921

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

594928

PMIP
Mitochondrial intermediate peptidase

1

2

High-throughput

0.479

High

594932

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.479

High

594934

ETR1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

5

High-throughput

0.479

High

594938

GRPE
GrpE protein homolog, mitochondrial

1

1

High-throughput

0.479

High

594941

YLF2
Obg-like ATPase homolog

1

3

High-throughput

0.479

High

594949

SYPM
Probable proline--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

594951

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

4

High-throughput

0.479

High

594964

ETFB
Probable electron transfer flavoprotein subunit beta

1

2

High-throughput

0.479

High

594966

DLD2
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2

1

3

High-throughput

0.479

High

594968

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.479

High

594969

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

1

1

High-throughput

0.479

High

594970

GCST
Aminomethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

594973

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

3

High-throughput

0.479

High

594975

LYS4
Homoaconitase, mitochondrial

1

5

High-throughput

0.479

High

594981

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.479

High

594982

FMP41
Oxaloacetate tautomerase FMP41, mitochondrial

1

1

High-throughput

0.479

High

594991

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

1

High-throughput

0.479

High

594993

RT17
Small ribosomal subunit protein uS17m

1

3

High-throughput

0.479

High

595000

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

4

High-throughput

0.479

High

595008

COQ10
Coenzyme Q-binding protein COQ10, mitochondrial

1

1

High-throughput

0.479

High

595013

YOR22
Probable phospholipase YOR022C, mitochondrial

1

2

High-throughput

0.479

High

595018

RM23
Large ribosomal subunit protein uL13m

1

2

High-throughput

0.479

High

595020

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

595006

LEC1
PX domain-containing protein LEC1

1

0

Small-scale

0.460

High

150063

COQ4
Ubiquinone biosynthesis protein COQ4, mitochondrial

1

0

High-throughput

0.458

High

361469

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

397519

CBP2
Cytochrome B pre-mRNA-processing protein 2

1

0

High-throughput

0.458

High

416514

HXKB
Hexokinase-2

1

0

High-throughput

0.458

High

439077

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

452624

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

456324

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

514428

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

518707

ADH4
Alcohol dehydrogenase 4

1

0

High-throughput

0.458

High

554549

RM02
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.458

High

594163

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

594872

ATP10
Mitochondrial ATPase complex subunit ATP10

1

0

High-throughput

0.458

High

594876

RM33
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.458

High

594880

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.458

High

594888

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

594889

IMG1
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.458

High

594890

IMG2
Large ribosomal subunit protein mL49

1

0

High-throughput

0.458

High

594898

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.458

High

594910

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.458

High

594915

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

594918

RM06
Large ribosomal subunit protein uL6m

1

0

High-throughput

0.458

High

594926

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.458

High

594930

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

594931

RM24
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.458

High

594933

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.458

High

594935

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.458

High

594940

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

594944

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

594946

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

594950

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.458

High

594952

AIM9
Altered inheritance of mitochondria protein 9, mitochondrial

1

0

High-throughput

0.458

High

594954

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.458

High

594959

RN49
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.458

High

594960

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

594963

RT18
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.458

High

594974

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

594976

ALAT1
Alanine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

594978

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

594984

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

594987

ABF2
ARS-binding factor 2, mitochondrial

1

0

High-throughput

0.458

High

594988

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

594989

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.458

High

594990

ESP1
Separin

1

0

High-throughput

0.458

High

594992

RT10
Small ribosomal subunit protein uS10m

1

0

High-throughput

0.458

High

594996

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

594998

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

594999

COQ11
MIOREX complex component 2

1

0

High-throughput

0.458

High

595001

RRG8
Required for respiratory growth protein 8, mitochondrial

1

0

High-throughput

0.458

High

595004

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.458

High

595005

RM35
Large ribosomal subunit protein mL38

1

0

High-throughput

0.458

High

595007

POS5
NADH kinase POS5, mitochondrial

1

0

High-throughput

0.458

High

595009

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

595011

LEU9
2-isopropylmalate synthase 2, mitochondrial

1

0

High-throughput

0.458

High

595012

RRG1
Required for respiratory growth protein 1, mitochondrial

1

0

High-throughput

0.458

High

509376

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

2

High-throughput

0.457

High

517877

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.457

High

470098

SPS1
Sporulation-specific protein 1

1

3

High-throughput

0.457

High

594911

CDC12
Cell division control protein 12

1

1

High-throughput

0.457

High

594945

TEM1
Protein TEM1

1

5

High-throughput

0.457

High

453404

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

392167

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.437

High

441678

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

502822

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

513816

RS11B
Small ribosomal subunit protein uS17B

1

3

High-throughput

0.437

High

581818

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

594883

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

594887

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

594919

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

594920

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.437

High

594923

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

594927

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

594929

CENPA
Histone H3-like centromeric protein CSE4

1

4

High-throughput

0.437

High

594994

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

595016

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

595017

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

595019

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.437

High

543708

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

594953

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.407

High

594913

SMI1
Cell wall assembly regulator SMI1

2

0

Small-scale

0.307

High

594958

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

366637

ARGI
Arginase

1

0

High-throughput

0.261

Low

448127

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.261

Low

449275

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

568913

INO4
Protein INO4

1

0

High-throughput

0.261

Low

594909

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.261

Low

594937

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.261

Low

594939

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.261

Low

594983

IGO1
mRNA stability protein IGO1

1

0

High-throughput

0.261

Low

594957

MPH1
ATP-dependent DNA helicase MPH1

1

0

Small-scale

0.251

Low

268862

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

383492

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

427123

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.249

Low

434789

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435744

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

504014

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512789

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

558559

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

594899

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

594901

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

594908

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

594922

SPC29
Spindle pole component 29

1

0

High-throughput

0.249

Low

594924

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.249

Low

594936

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.249

Low

594942

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

594943

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

594948

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

594955

NAGS
Amino-acid acetyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

594967

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

594971

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

594972

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

594977

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

594980

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.249

Low

594986

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

594995

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

594997

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.249

Low

595002

SEC10
Exocyst complex component SEC10

1

0

Small-scale

0.249

Low

595003

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

595010

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.249

Low

595015

ARP8
Actin-like protein ARP8

1

0

High-throughput

0.249

Low

575373

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

594947

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

594962

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

595014

MAM3
Protein MAM3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025