HitPredict - High confidence protein-protein interactions

Interactor 1: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.99	1.00	0.997

Property	Details
Experiments	11927552, 25609649, 12794086, 27703004, 11027280, 9288972, 31591477, 31932471, 10531362, 18783722, 15817471, 12808092, 19135894, 10878024, 21532621, 12621041, 15761153, 17591701, 9111321, 15467747 and 39 others more... 15231748, 19139564, 24584437, 25514493, 26555259, 28468752, 28443643, 10199400, 11264182, 12419246, 9311995, 11274206, 9892009, 33961781, 11114293, 11102446, 35811497, 12732634, 12167862, 10781087, 16751102, 10085121, 17283070, 19917253, 16916642, 18729074, 15922743, 15350224, 12543979, 23788427, 21988832, 24157709, 15613484, 17272273, 20211142, 21297662, 11779503, 18511908, 9389648
Identification Methods	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation, two hybrid array, molecular sieving, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	MH1~MH1, MH2~MH2
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001701 - in utero embryonic development and 33 others more... GO:0003682 - chromatin binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006351 - DNA-templated transcription GO:0006355 - regulation of DNA-templated transcription GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0008283 - cell population proliferation GO:0008285 - negative regulation of cell population proliferation GO:0009653 - anatomical structure morphogenesis GO:0010628 - positive regulation of gene expression GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0017015 - regulation of transforming growth factor beta receptor signaling pathway GO:0030154 - cell differentiation GO:0030325 - adrenal gland development GO:0032444 - activin responsive factor complex GO:0032924 - activin receptor signaling pathway GO:0035556 - intracellular signal transduction GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding GO:0060395 - SMAD protein signal transduction GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0062009 - secondary palate development GO:0070411 - I-SMAD binding GO:0070412 - R-SMAD binding GO:0071141 - SMAD protein complex GO:0071144 - heteromeric SMAD protein complex GO:0071333 - cellular response to glucose stimulus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	552
Hs

1	467

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Last updated: 15 Jul 2024