HitPredict

Interactor 1: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Interactor 2: PAPP2 (Q9BXP8)
Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E)
Gene: PAPPA2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.50	0.464

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 552 Hs			1 1791
+	Hs
		171392 SMAD9_HUMAN (20-546): 0: 535: 34.28		PAPP1_HUMAN (263-1790): 0: 2057: 45.66
+	Hs
		950163 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		PAPP1_HUMAN (263-1790): 0: 2057: 45.66
+	Hs
		1028132 SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65		PAPP1_HUMAN (263-1790): 0: 2057: 45.66
+	Hs
		1035611 SMAD4_HUMAN (1-552): 0: 696: 100.00		TEN3_HUMAN (1244-1549): 5.01e-19: 96.8: 12.81
+	Hs
		1035564 SMAD4_HUMAN (1-552): 0: 696: 100.00		NOTC4_HUMAN (1286-1659): 8.92e-15: 82.5: 12.44
+	Hs
		441720 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		CFAH_HUMAN (1325-1762): 3.61e-33: 142: 13.59
+	Hs
		171403 SMAD9_HUMAN (20-546): 0: 535: 34.28		SVEP1_HUMAN (1237-1591): 6.18e-09: 63.7: 9.90
+	Hs
		950260 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		NOTC4_HUMAN (1286-1659): 8.92e-15: 82.5: 12.44
+	Hs
		950199 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		SVEP1_HUMAN (1237-1591): 6.18e-09: 63.7: 9.90
+	Hs
		950250 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		CSMD1_HUMAN (1392-1651): 6.49e-09: 63.7: 12.31
+	Hs
		1078639 SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65		NOTC4_HUMAN (1286-1659): 8.92e-15: 82.5: 12.44