HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33545068
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PB1~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 1235
+	Hs
		148772 SQSTM_HUMAN (1-440): 0: 760: 100.00		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Rn
		139624 SQSTM_RAT (1-440): 0: 746: 90.95		KPCL_RAT (1-362): 1.03e-120: 391: 25.13
+	Hs
		1036549 SQSTM_HUMAN (1-440): 0: 760: 100.00		KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25
+	Hs
		1037010 SQSTM_HUMAN (1-440): 0: 760: 100.00		KCC2A_HUMAN (31-423): 1.9e-113: 364: 25.25
+	Hs
		1023037 SQSTM_HUMAN (1-440): 0: 760: 100.00		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	Hs
		1027359 SQSTM_HUMAN (1-440): 0: 760: 100.00		STK3_HUMAN (30-307): 1.02e-62: 224: 43.42
+	Hs
		1036779 SQSTM_HUMAN (1-440): 0: 760: 100.00		M4K1_HUMAN (29-341): 1.52e-59: 223: 37.42
+	Mm
		949284 HERC2_MOUSE (120-197): 2.07e-12: 71.7: 32.50		TNIK_MOUSE (29-323): 2.89e-55: 213: 40.59