HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.956

The method score is based on:

Property Details
Experiments 32835772, 33545068, 34996837, 25972374, 27035970, 31810986, 37506885
Identification Methods affinity chromatography technology, proximity labelling technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PB1~Pkinase
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0010508 - positive regulation of autophagy
GO:0043231 - intracellular membrane-bounded organelle
and 1 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 440
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024