Interactor 1: ATR (Q13535)
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
Gene: ATR

Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 0.60 0.713

The method score is based on:

Property Details
Experiments 28439015, 30940728, 24081328, 23226797, 19097996
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
and 4 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 2644
Hs

1 1522
+ Xl
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+ Sc
+ Sp
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024