HitPredict

Interactor 1: GSTM4 (Q03013)
Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20)
Gene: GSTM4

Interactor 2: Q6FGJ9 (Q6FGJ9)
Glutathione S-transferase (EC 2.5.1.18)
Gene: GSTM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GST_C~GST_C, GST_C~GST_N, GST_N~GST_N
Common GO terms	GO:0004364 - glutathione transferase activity GO:0005829 - cytosol GO:0006749 - glutathione metabolic process GO:0045171 - intercellular bridge
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 225
+	Hs
		636818 GSTM2_HUMAN (1-218): 1.32e-71: 218: 83.03		GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00
+	Hs
		636842 GSTM4_HUMAN (1-218): 2.09e-71: 218: 100.00		GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00
+	Hs
		1232343 Q6FGJ9_HUMAN (2-218): 7.7e-70: 214: 72.35		Q6FGJ9_HUMAN (1-225): 3.63e-76: 230: 100.00
+	Hs
		482709 GSTM1_HUMAN (1-218): 6.43e-70: 214: 86.70		GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00
+	Hs
		636815 GSTM3_HUMAN (2-218): 7.7e-70: 214: 72.35		GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00
+	Hs
		1040469 GSTM4_HUMAN (1-218): 2.09e-71: 218: 100.00		GSTM4_HUMAN (6-222): 7.36e-70: 214: 72.35
+	Hs
		701321 GSTM2_HUMAN (1-218): 1.32e-71: 218: 83.03		GSTM2_HUMAN (6-222): 7.86e-70: 214: 68.66
+	Hs
		701327 GSTM4_HUMAN (1-218): 2.09e-71: 218: 100.00		GSTM2_HUMAN (6-222): 7.86e-70: 214: 68.66
+	Hs
		482711 GSTM2_HUMAN (1-218): 1.32e-71: 218: 83.03		GSTM1_HUMAN (6-222): 4.17e-69: 212: 72.81
+	Rn
		418770 GSTM1_RAT (1-218): 1.81e-69: 213: 73.85		GSTM1_RAT (6-222): 3.5e-69: 212: 67.74
+	Hs
		701323 GSTM2_HUMAN (1-218): 1.32e-71: 218: 83.03		GSTM5_HUMAN (6-222): 1.47e-64: 200: 71.89
+	Hs
		857051 GSTM4_HUMAN (1-218): 2.09e-71: 218: 100.00		GSTM5_HUMAN (6-222): 1.47e-64: 200: 71.89
+	Hs
		482713 GSTM1_HUMAN (1-218): 6.43e-70: 214: 86.70		GSTM5_HUMAN (6-222): 1.47e-64: 200: 71.89
+	Hs
		636830 GSTM3_HUMAN (2-218): 7.7e-70: 214: 72.35		GSTM5_HUMAN (6-222): 1.47e-64: 200: 71.89
+	Hs
		857053 Q6FGJ9_HUMAN (2-218): 7.7e-70: 214: 72.35		GSTM5_HUMAN (6-222): 1.47e-64: 200: 71.89