HitPredict

Interactor 1: GSTM3 (P21266)
Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)
Gene: GSTM3

Interactor 2: GSTM5 (P46439)
Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5)
Gene: GSTM5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	25416956, 26186194, 28514442, 32296183, 33961781, 31515488, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach, mammalian protein protein interaction trap, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	GST_C~GST_C, GST_C~GST_N, GST_N~GST_N
Common GO terms	GO:0004364 - glutathione transferase activity GO:0005829 - cytosol GO:0006749 - glutathione metabolic process GO:0045171 - intercellular bridge
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 218
+	Hs
		636818 GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00		GSTM2_HUMAN (1-218): 2.53e-71: 217: 81.19
+	Hs
		482709 GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00		GSTM1_HUMAN (1-218): 6.52e-70: 214: 87.62
+	Hs
		1040476 Q6FGJ9_HUMAN (1-225): 3.63e-76: 230: 100.00		GSTM4_HUMAN (1-218): 1.38e-69: 213: 83.03
+	Hs
		636842 GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00		GSTM4_HUMAN (1-218): 1.38e-69: 213: 83.03
+	Hs
		1232343 Q6FGJ9_HUMAN (1-225): 3.63e-76: 230: 100.00		Q6FGJ9_HUMAN (2-218): 4.1e-69: 212: 71.89
+	Hs
		636815 GSTM3_HUMAN (1-225): 3.63e-76: 230: 100.00		GSTM3_HUMAN (2-218): 4.1e-69: 212: 71.89
+	Hs
		701321 GSTM2_HUMAN (6-222): 7.86e-70: 214: 68.66		GSTM2_HUMAN (1-218): 2.53e-71: 217: 81.19
+	Hs
		701327 GSTM4_HUMAN (6-222): 7.36e-70: 214: 72.35		GSTM2_HUMAN (1-218): 2.53e-71: 217: 81.19
+	Hs
		857053 Q6FGJ9_HUMAN (1-225): 3.63e-76: 230: 100.00		GSTM5_HUMAN (1-218): 1.41e-64: 200: 100.00
+	Hs
		482711 GSTM2_HUMAN (6-222): 7.86e-70: 214: 68.66		GSTM1_HUMAN (1-218): 6.52e-70: 214: 87.62
+	Hs
		1040469 GSTM4_HUMAN (6-222): 7.36e-70: 214: 72.35		GSTM4_HUMAN (1-218): 1.38e-69: 213: 83.03
+	Rn
		418770 GSTM1_RAT (6-222): 3.5e-69: 212: 67.74		GSTM1_RAT (1-218): 1.46e-68: 210: 77.52
+	Hs
		701323 GSTM2_HUMAN (6-222): 7.86e-70: 214: 68.66		GSTM5_HUMAN (1-218): 1.41e-64: 200: 100.00
+	Hs
		857051 GSTM4_HUMAN (6-222): 7.36e-70: 214: 72.35		GSTM5_HUMAN (1-218): 1.41e-64: 200: 100.00