HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: UB2E3 (Q969T4)
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
Gene: UBE2E3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19256485
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 207
+	Hs
		1042304 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2E2_HUMAN (1-207): 5.59e-89: 261: 85.02
+	Hs
		919724 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07
+	Hs
		849325 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		851812 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36
+	Hs
		896438 CUL3_HUMAN (1-768): 0: 951: 100.00		UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27
+	Hs
		1043149 CUL4A_HUMAN (10-768): 0: 791: 38.32		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	Hs
		849326 CUL4A_HUMAN (10-768): 0: 791: 38.32		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Hs
		895791 CUL4A_HUMAN (10-768): 0: 791: 38.32		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		895792 CUL4B_HUMAN (5-768): 0: 779: 36.77		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Hs
		828994 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBE2A_HUMAN (59-204): 1.17e-69: 210: 35.62
+	Hs
		1041136 CUL1_HUMAN (18-768): 0: 707: 30.57		UB2E3_HUMAN (1-207): 5.71e-90: 264: 100.00
+	At
		1228143 CUL4_ARATH (8-768): 0: 744: 38.61		COP10_ARATH (49-206): 2.61e-73: 221: 56.33
+	Hs
		849324 CUL2_HUMAN (30-768): 0: 672: 26.17		UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64
+	Dm
		639393 CUL1_DROME (29-768): 0: 669: 27.49		UBCD1_DROME (61-206): 9.93e-82: 241: 64.38
+	Hs
		895790 CUL2_HUMAN (30-768): 0: 672: 26.17		UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38
+	Sp
		804458 CUL3_SCHPO (11-768): 0: 648: 37.04		UBC4_SCHPO (61-206): 5.98e-81: 239: 65.07