Protein: TP4A2
Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)

Gene: TP4A2, PTP4A2
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q12974

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0004857 - enzyme inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091816

CNNM4
Metal transporter CNNM4

7

10

High-throughput

0.967

High

1091825

CNNM3
Metal transporter CNNM3

6

10

Small-scale

0.953

High

1091843

CNNM1
Metal transporter CNNM1

5

10

High-throughput

0.933

High

1091840

CNNM2
Metal transporter CNNM2

5

10

High-throughput

0.930

High

1091802

TP4A2
Protein tyrosine phosphatase type IVA 2

2

15

Small-scale

0.768

High

1091830

TP4A1
Protein tyrosine phosphatase type IVA 1

10

16

Small-scale

0.754

High

921533

PGTB2
Geranylgeranyl transferase type-2 subunit beta

5

4

Small-scale

0.719

High

277349

TP4A3
Protein tyrosine phosphatase type IVA 3

4

16

High-throughput

0.699

High

881658

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

3

2

High-throughput

0.662

High

1091820

EFL1
Elongation factor-like GTPase 1

2

6

High-throughput

0.628

High

1091846

FMN2
Formin-2

2

3

High-throughput

0.628

High

1091854

PCDB5
Protocadherin beta-5

2

1

High-throughput

0.628

High

907403

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

8

High-throughput

0.621

High

619043

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

High-throughput

0.618

High

710823

EPHB2
Ephrin type-B receptor 2

1

12

High-throughput

0.618

High

212567

GPAA1
GPI-anchor transamidase component GPAA1

2

0

High-throughput

0.602

High

881705

FNTB
Protein farnesyltransferase subunit beta

2

4

High-throughput

0.601

High

934539

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.589

High

1091809

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.585

High

968895

PRS8
26S proteasome regulatory subunit 8

1

3

High-throughput

0.554

High

1028749

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

16

High-throughput

0.536

High

1091808

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

12

High-throughput

0.536

High

1091842

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

4

High-throughput

0.536

High

335280

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

1

High-throughput

0.515

High

1091812

USF2
Upstream stimulatory factor 2

1

3

High-throughput

0.515

High

207516

DHX15
ATP-dependent RNA helicase DHX15

1

3

Small-scale

0.501

High

461415

HS90A
Heat shock protein HSP 90-alpha

1

8

Small-scale

0.501

High

468317

HS90B
Heat shock protein HSP 90-beta

1

8

Small-scale

0.501

High

1032930

EWS
RNA-binding protein EWS

1

2

Small-scale

0.501

High

1091829

WIPF2
WAS/WASL-interacting protein family member 2

1

1

Small-scale

0.501

High

1091844

DUS22
Dual specificity protein phosphatase 22

1

5

Small-scale

0.501

High

1091850

AKP8L
A-kinase anchor protein 8-like

1

3

Small-scale

0.501

High

425726

PERM
Myeloperoxidase

1

0

Small-scale

0.480

High

884589

SYCC
Cysteine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.480

High

124046

SNP23
Synaptosomal-associated protein 23

1

1

Small-scale

0.479

High

160262

GOSR2
Golgi SNAP receptor complex member 2

1

3

Small-scale

0.479

High

160888

STX16
Syntaxin-16

1

5

Small-scale

0.479

High

189541

STX7
Syntaxin-7

1

5

Small-scale

0.479

High

226016

STX6
Syntaxin-6

1

2

Small-scale

0.479

High

230017

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

8

High-throughput

0.479

High

243933

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

5

High-throughput

0.479

High

293638

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

343364

SNP29
Synaptosomal-associated protein 29

1

1

Small-scale

0.479

High

540427

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

Small-scale

0.479

High

562035

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

Small-scale

0.479

High

605997

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.479

High

637017

VATB2
V-type proton ATPase subunit B, brain isoform

1

1

Small-scale

0.479

High

646829

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

703564

MK01
Mitogen-activated protein kinase 1

1

13

High-throughput

0.479

High

716543

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

9

High-throughput

0.479

High

720754

PUR8
Adenylosuccinate lyase

1

2

High-throughput

0.479

High

746196

STX2
Syntaxin-2

1

5

Small-scale

0.479

High

800481

VATA
V-type proton ATPase catalytic subunit A

1

3

Small-scale

0.479

High

899865

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.479

High

933000

SNAA
Alpha-soluble NSF attachment protein

1

1

Small-scale

0.479

High

963410

STXB1
Syntaxin-binding protein 1

1

1

Small-scale

0.479

High

1037474

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.479

High

1087092

STX4
Syntaxin-4

1

5

Small-scale

0.479

High

1089191

TRI26
Tripartite motif-containing protein 26

1

1

High-throughput

0.479

High

1091803

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

4

High-throughput

0.479

High

1091804

PRDX4
Peroxiredoxin-4

1

9

High-throughput

0.479

High

1091805

STX5
Syntaxin-5

1

6

Small-scale

0.479

High

1091806

STX3
Syntaxin-3

1

5

Small-scale

0.479

High

1091807

FHL3
Four and a half LIM domains protein 3

1

6

High-throughput

0.479

High

1091810

TRBP2
RISC-loading complex subunit TARBP2

1

4

High-throughput

0.479

High

1091811

VAMP3
Vesicle-associated membrane protein 3

1

2

Small-scale

0.479

High

1091813

MK14
Mitogen-activated protein kinase 14

1

12

High-throughput

0.479

High

1091815

LTOR1
Ragulator complex protein LAMTOR1

1

1

Small-scale

0.479

High

1091821

AROS
Active regulator of SIRT1

1

2

High-throughput

0.479

High

1091824

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1091826

FAD1
FAD synthase

1

2

High-throughput

0.479

High

1091831

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

3

Small-scale

0.479

High

1091833

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

11

High-throughput

0.479

High

1091835

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1091838

VAMP8
Vesicle-associated membrane protein 8

1

3

Small-scale

0.479

High

1091839

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1091841

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

2

High-throughput

0.479

High

1091847

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

3

Small-scale

0.479

High

1091851

STX8
Syntaxin-8

1

3

Small-scale

0.479

High

219163

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.458

High

276833

VATG1
V-type proton ATPase subunit G 1

1

0

Small-scale

0.458

High

331858

GOSR1
Golgi SNAP receptor complex member 1

1

0

Small-scale

0.458

High

333330

SNAPN
SNARE-associated protein Snapin

1

0

Small-scale

0.458

High

637100

VATC1
V-type proton ATPase subunit C 1

1

0

Small-scale

0.458

High

784785

VATE1
V-type proton ATPase subunit E 1

1

0

Small-scale

0.458

High

926172

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.458

High

943043

STX17
Syntaxin-17

1

0

Small-scale

0.458

High

1008466

BL1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

Small-scale

0.458

High

1088649

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

1091814

VATF
V-type proton ATPase subunit F

1

0

Small-scale

0.458

High

1091819

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

Small-scale

0.458

High

1091832

A7L3B
Ataxin-7-like protein 3B

1

0

High-throughput

0.458

High

1091837

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.458

High

1091848

LTOR3
Ragulator complex protein LAMTOR3

1

0

Small-scale

0.458

High

1091849

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

Small-scale

0.458

High

1091853

LTOR2
Ragulator complex protein LAMTOR2

1

0

Small-scale

0.458

High

1091855

VATD
V-type proton ATPase subunit D

1

0

Small-scale

0.458

High

827389

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.457

High

280190

SC22B
Vesicle-trafficking protein SEC22b

1

1

Small-scale

0.437

High

1091817

RL22L
Ribosomal protein eL22-like

1

2

High-throughput

0.437

High

1091822

STX12
Syntaxin-12

1

5

Small-scale

0.437

High

1091823

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

8

High-throughput

0.437

High

1091827

G45IP
Large ribosomal subunit protein mL64

1

3

High-throughput

0.437

High

1091834

SNAG
Gamma-soluble NSF attachment protein

1

4

Small-scale

0.437

High

1091845

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

2

High-throughput

0.437

High

1091818

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

1091852

CP8B1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

1

0

High-throughput

0.279

Low

1091828

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

Small-scale

0.249

Low

1091836

KXDL1
KxDL motif-containing protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025