Protein: DHX35
Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35)

Gene: DHX35
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9H5Z1

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0001701 - in utero embryonic development
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1412028

WDR83
WD repeat domain-containing protein 83

4

20

High-throughput

0.892

High

222529

PLRG1
Pleiotropic regulator 1

2

20

High-throughput

0.811

High

1387560

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

13

High-throughput

0.691

High

1201282

EAPP
E2F-associated phosphoprotein

3

2

High-throughput

0.667

High

1290728

ZCH18
Zinc finger CCCH domain-containing protein 18

3

11

High-throughput

0.667

High

1415989

YJU2
Splicing factor YJU2

3

5

High-throughput

0.667

High

973822

RUXE
Small nuclear ribonucleoprotein E

3

2

High-throughput

0.662

High

974046

RUXF
Small nuclear ribonucleoprotein F

3

11

High-throughput

0.662

High

1410074

USB1
U6 snRNA phosphodiesterase 1

3

0

High-throughput

0.638

High

1434800

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

2

High-throughput

0.633

High

351356

SYF2
Pre-mRNA-splicing factor SYF2

2

2

High-throughput

0.628

High

991250

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

11

High-throughput

0.628

High

1093051

CDC16
Cell division cycle protein 16 homolog

2

3

High-throughput

0.628

High

1434794

PRP19
Pre-mRNA-processing factor 19

2

20

High-throughput

0.628

High

346330

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.618

High

974197

RUXG
Small nuclear ribonucleoprotein G

2

16

High-throughput

0.611

High

1434795

PPIE
Peptidyl-prolyl cis-trans isomerase E

2

5

High-throughput

0.611

High

1256736

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1255545

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

876725

HSP13
Heat shock 70 kDa protein 13

1

8

High-throughput

0.541

High

259110

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.536

High

298080

SPF27
Pre-mRNA-splicing factor SPF27

1

3

High-throughput

0.536

High

574470

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

9

High-throughput

0.536

High

974844

SMD3
Small nuclear ribonucleoprotein Sm D3

1

10

High-throughput

0.536

High

1111272

SNW1
SNW domain-containing protein 1

1

9

High-throughput

0.536

High

1138638

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

12

High-throughput

0.536

High

1144160

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1356570

CCD12
Coiled-coil domain-containing protein 12

1

1

High-throughput

0.536

High

1417879

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1434788

DJC17
DnaJ homolog subfamily C member 17

1

4

High-throughput

0.536

High

1434793

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

6

High-throughput

0.536

High

1434798

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

1

High-throughput

0.536

High

860002

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

347326

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

1348959

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

173360

XPO1
Exportin-1

1

5

High-throughput

0.479

High

386234

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.479

High

521937

H14
Histone H1.4

1

6

High-throughput

0.479

High

564372

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

589686

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

769177

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

905145

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

971080

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

998810

H31
Histone H3.1

1

5

High-throughput

0.479

High

1138061

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.479

High

1326342

NIN
Ninein

1

4

High-throughput

0.479

High

1329871

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1434789

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1434791

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

71615

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

16

High-throughput

0.445

High

765892

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.445

High

1203260

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.437

High

1226269

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.437

High

1256592

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.437

High

1403073

CEP89
Centrosomal protein of 89 kDa

1

6

High-throughput

0.437

High

1434787

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.437

High

1434792

XPO7
Exportin-7

1

5

High-throughput

0.437

High

1434797

NINL
Ninein-like protein

1

5

High-throughput

0.437

High

239209

ZNRD2
Protein ZNRD2

1

2

High-throughput

0.407

High

1434799

NGN3
Neurogenin-3

3

0

High-throughput

0.345

High

1383601

K1143
Uncharacterized protein KIAA1143

2

0

High-throughput

0.328

High

706311

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

1311522

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.279

Low

1434796

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.249

Low

58932

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

1434790

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025