HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: PEF1 (Q9UBV8)
Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)
Gene: PEF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	27716508, 35120648, 21145461
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0048208 - COPII vesicle coating GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 284
+	Hs
		427884 CUL3_HUMAN (1-768): 0: 951: 100.00		CAN1_HUMAN (101-280): 6.94e-57: 195: 23.53
+	Hs
		568979 CUL3_HUMAN (1-768): 0: 951: 100.00		CAN2_HUMAN (109-277): 6.52e-56: 192: 24.43
+	Hs
		385867 CUL3_HUMAN (1-768): 0: 951: 100.00		CPNS1_HUMAN (90-282): 2.22e-48: 163: 22.50
+	Hs
		259731 CUL3_HUMAN (1-768): 0: 951: 100.00		PDCD6_HUMAN (115-281): 1.97e-48: 161: 42.52
+	Hs
		1041811 CUL3_HUMAN (1-768): 0: 951: 100.00		CAN13_HUMAN (112-280): 4.1e-20: 92: 16.85
+	Hs
		259729 CUL1_HUMAN (18-768): 0: 707: 30.57		PDCD6_HUMAN (115-281): 1.97e-48: 161: 42.52
+	Hs
		259730 CUL2_HUMAN (30-768): 0: 672: 26.17		PDCD6_HUMAN (115-281): 1.97e-48: 161: 42.52
+	Hs
		259766 CUL5_HUMAN (25-768): 0: 597: 23.77		PDCD6_HUMAN (115-281): 1.97e-48: 161: 42.52