Protein: VIPR2
Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R)

Gene: VIPR2
Organism: Homo sapiens
Interactions: 236
UniProt ID: P41587

Gene Ontology (top 5):
GO:0001634 - pituitary adenylate cyclase-activating polypeptide receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0004999 - vasoactive intestinal polypeptide receptor activity
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

835256

AGRE5
Adhesion G protein-coupled receptor E5

1

6

High-throughput

0.691

High

835428

AGRG1
Adhesion G-protein coupled receptor G1

1

4

High-throughput

0.691

High

835273

SNX17
Sorting nexin-17

3

1

High-throughput

0.662

High

835335

CIP2A
Protein CIP2A

3

2

High-throughput

0.662

High

835381

YIPF3
Protein YIPF3

3

3

High-throughput

0.662

High

835398

GPC5C
G-protein coupled receptor family C group 5 member C

3

5

High-throughput

0.662

High

835362

SPTCS
Spatacsin

3

0

High-throughput

0.634

High

184403

SURF4
Surfeit locus protein 4

2

2

High-throughput

0.628

High

256001

S19A2
Thiamine transporter 1

2

5

High-throughput

0.628

High

336529

PIGN
GPI ethanolamine phosphate transferase 1

2

9

High-throughput

0.628

High

443697

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

4

High-throughput

0.628

High

480735

LEG1
Galectin-1

2

2

High-throughput

0.628

High

680259

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

2

4

High-throughput

0.628

High

719871

HMOX2
Heme oxygenase 2

2

1

High-throughput

0.628

High

835254

MTOR
Serine/threonine-protein kinase mTOR

2

7

High-throughput

0.628

High

835263

CXCR4
C-X-C chemokine receptor type 4

2

6

High-throughput

0.628

High

835279

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

2

High-throughput

0.628

High

835294

LMBD2
G-protein coupled receptor-associated protein LMBRD2

2

1

High-throughput

0.628

High

835348

CDS1
Phosphatidate cytidylyltransferase 1

2

2

High-throughput

0.628

High

835357

COQ8B
Atypical kinase COQ8B, mitochondrial

2

5

High-throughput

0.628

High

835399

SERC1
Serine incorporator 1

2

2

High-throughput

0.628

High

835411

S39A1
Zinc transporter ZIP1

2

11

High-throughput

0.628

High

245435

OPA1
Dynamin-like GTPase OPA1, mitochondrial

3

1

High-throughput

0.604

High

835284

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

3

6

High-throughput

0.604

High

835295

RINT1
RAD50-interacting protein 1

3

1

High-throughput

0.604

High

835307

DYM
Dymeclin

3

3

High-throughput

0.604

High

835327

VPS8
Vacuolar protein sorting-associated protein 8 homolog

3

1

High-throughput

0.604

High

835330

F241A
Uncharacterized protein FAM241A

3

1

High-throughput

0.604

High

835353

TM186
Transmembrane protein 186

3

1

High-throughput

0.604

High

835391

REEP4
Receptor expression-enhancing protein 4

3

4

High-throughput

0.604

High

835402

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

3

2

High-throughput

0.604

High

835423

RBGP1
Rab GTPase-activating protein 1

3

9

High-throughput

0.604

High

835425

TNPO3
Transportin-3

3

7

High-throughput

0.604

High

835395

VEZA
Vezatin

2

0

High-throughput

0.602

High

506570

GPHRB
Golgi pH regulator B

3

9

High-throughput

0.578

High

173674

BTAF1
TATA-binding protein-associated factor 172

2

4

High-throughput

0.574

High

226415

SNG2
Synaptogyrin-2

2

6

High-throughput

0.574

High

230881

ORC5
Origin recognition complex subunit 5

2

1

High-throughput

0.574

High

295909

SC5D
Lathosterol oxidase

2

3

High-throughput

0.574

High

397670

NU4M
NADH-ubiquinone oxidoreductase chain 4

2

3

High-throughput

0.574

High

665072

COT2
COUP transcription factor 2

2

3

High-throughput

0.574

High

835270

MTX1
Metaxin-1

2

4

High-throughput

0.574

High

835275

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

2

High-throughput

0.574

High

835286

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

2

3

High-throughput

0.574

High

835290

S35F1
Solute carrier family 35 member F1

2

10

High-throughput

0.574

High

835291

TM164
Transmembrane protein 164

2

1

High-throughput

0.574

High

835300

BRAT1
Integrator complex assembly factor BRAT1

2

1

High-throughput

0.574

High

835301

HACD2
Very-long-chain

2

3

High-throughput

0.574

High

835303

CERS6
Ceramide synthase 6

2

8

High-throughput

0.574

High

835308

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

3

High-throughput

0.574

High

835309

SETX
Probable helicase senataxin

2

1

High-throughput

0.574

High

835313

ADCK1
AarF domain-containing protein kinase 1

2

5

High-throughput

0.574

High

835322

S35F2
Solute carrier family 35 member F2

2

10

High-throughput

0.574

High

835324

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

5

High-throughput

0.574

High

835328

CERS5
Ceramide synthase 5

2

8

High-throughput

0.574

High

835350

FAKD4
FAST kinase domain-containing protein 4

2

6

High-throughput

0.574

High

835355

EVI5L
EVI5-like protein

2

4

High-throughput

0.574

High

835356

F241B
Protein FAM241B

2

1

High-throughput

0.574

High

835360

CERS2
Ceramide synthase 2

2

8

High-throughput

0.574

High

835365

CP2S1
Cytochrome P450 2S1

2

4

High-throughput

0.574

High

835366

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

2

1

High-throughput

0.574

High

835369

GCP2
Gamma-tubulin complex component 2

2

3

High-throughput

0.574

High

835379

XPO4
Exportin-4

2

6

High-throughput

0.574

High

835390

SG196
Protein O-mannose kinase

2

3

High-throughput

0.574

High

835400

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

7

High-throughput

0.574

High

835403

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

2

High-throughput

0.574

High

835410

ELOV2
Very long chain fatty acid elongase 2

2

6

High-throughput

0.574

High

835412

VPS18
Vacuolar protein sorting-associated protein 18 homolog

2

2

High-throughput

0.574

High

835417

XPO7
Exportin-7

2

9

High-throughput

0.574

High

835421

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

2

1

High-throughput

0.574

High

85243

RBG10
Rab GTPase-activating protein 1-like, isoform 10

2

1

High-throughput

0.558

High

835259

SC5A3
Sodium/myo-inositol cotransporter

2

2

High-throughput

0.552

High

665540

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

2

High-throughput

0.549

High

835281

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

2

4

High-throughput

0.549

High

835285

YIF1B
Protein YIF1B

2

2

High-throughput

0.549

High

835287

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

2

9

High-throughput

0.549

High

835302

THADA
tRNA

2

1

High-throughput

0.549

High

835306

COX15
Heme A synthase COX15

2

1

High-throughput

0.549

High

835317

RETR3
Reticulophagy regulator 3

2

1

High-throughput

0.549

High

835320

ZDH13
Palmitoyltransferase ZDHHC13

2

5

High-throughput

0.549

High

835323

K2013
Uncharacterized protein KIAA2013

2

2

High-throughput

0.549

High

835325

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

2

2

High-throughput

0.549

High

835383

F234A
Protein FAM234A

2

1

High-throughput

0.549

High

835384

OSBL5
Oxysterol-binding protein-related protein 5

2

1

High-throughput

0.549

High

835393

COG4
Conserved oligomeric Golgi complex subunit 4

2

1

High-throughput

0.549

High

835394

XPO5
Exportin-5

2

8

High-throughput

0.549

High

296907

DGAT1
Diacylglycerol O-acyltransferase 1

1

2

High-throughput

0.536

High

419967

B3A2
Anion exchange protein 2

1

4

High-throughput

0.536

High

551966

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

565572

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

7

High-throughput

0.536

High

690195

STOM
Stomatin

1

1

High-throughput

0.536

High

723672

NTR1
Neurotensin receptor type 1

1

4

High-throughput

0.536

High

835258

CAV2
Caveolin-2

1

2

High-throughput

0.536

High

835260

AT12A
Potassium-transporting ATPase alpha chain 2

1

6

High-throughput

0.536

High

835268

CLN3
Battenin

1

3

High-throughput

0.536

High

835278

MSMO1
Methylsterol monooxygenase 1

1

3

High-throughput

0.536

High

835292

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.536

High

835299

S39A4
Zinc transporter ZIP4

1

11

High-throughput

0.536

High

835310

MAVS
Mitochondrial antiviral-signaling protein

1

2

High-throughput

0.536

High

835333

EXOC6
Exocyst complex component 6

1

1

High-throughput

0.536

High

835338

LRC15
Leucine-rich repeat-containing protein 15

1

2

High-throughput

0.536

High

835344

YLAT2
Y+L amino acid transporter 2

1

10

High-throughput

0.536

High

835349

GLMN
Glomulin

1

2

High-throughput

0.536

High

835370

YIPF4
Protein YIPF4

1

3

High-throughput

0.536

High

835401

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

7

High-throughput

0.536

High

835405

AIG1
Androgen-induced gene 1 protein

1

2

High-throughput

0.536

High

835409

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

4

High-throughput

0.536

High

835415

VATH
V-type proton ATPase subunit H

1

2

High-throughput

0.536

High

835427

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.536

High

835363

ERBIN
Erbin

1

1

Small-scale

0.527

High

220439

RGS14
Regulator of G-protein signaling 14

1

0

High-throughput

0.518

High

835255

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.513

High

835257

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.513

High

835336

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

0

High-throughput

0.513

High

85347

GPHRA
Golgi pH regulator A

2

9

High-throughput

0.504

High

421651

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

161198

EI24
Etoposide-induced protein 2.4 homolog

1

1

High-throughput

0.489

High

164543

TNPO2
Transportin-2

1

2

High-throughput

0.489

High

225362

ERD23
ER lumen protein-retaining receptor 3

1

4

High-throughput

0.489

High

254277

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

1

1

High-throughput

0.489

High

399666

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

3

High-throughput

0.489

High

664951

ERD21
ER lumen protein-retaining receptor 1

1

4

High-throughput

0.489

High

784535

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

2

High-throughput

0.489

High

835261

SYJ2B
Synaptojanin-2-binding protein

1

11

High-throughput

0.489

High

835264

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

1

High-throughput

0.489

High

835266

KDSR
3-ketodihydrosphingosine reductase

1

4

High-throughput

0.489

High

835274

OXA1L
Mitochondrial inner membrane protein OXA1L

1

1

High-throughput

0.489

High

835276

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.489

High

835277

DHC24
Delta(24)-sterol reductase

1

1

High-throughput

0.489

High

835283

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

5

High-throughput

0.489

High

835288

RABL3
Rab-like protein 3

1

6

High-throughput

0.489

High

835316

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

5

High-throughput

0.489

High

835321

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.489

High

835326

INT1
Integrator complex subunit 1

1

4

High-throughput

0.489

High

835332

ZNT7
Zinc transporter 7

1

7

High-throughput

0.489

High

835334

TBC15
TBC1 domain family member 15

1

7

High-throughput

0.489

High

835337

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

9

High-throughput

0.489

High

835339

COG1
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.489

High

835341

BRI3B
BRI3-binding protein

1

2

High-throughput

0.489

High

835346

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.489

High

835347

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

1

High-throughput

0.489

High

835351

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

835354

OTUL
Ubiquitin thioesterase otulin

1

1

High-throughput

0.489

High

835359

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

2

High-throughput

0.489

High

835361

TM41A
Transmembrane protein 41A

1

1

High-throughput

0.489

High

835372

DERL1
Derlin-1

1

1

High-throughput

0.489

High

835373

EFHD1
EF-hand domain-containing protein D1

1

1

High-throughput

0.489

High

835375

PTSS2
Phosphatidylserine synthase 2

1

2

High-throughput

0.489

High

835376

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

2

High-throughput

0.489

High

835377

ELOV1
Very long chain fatty acid elongase 1

1

6

High-throughput

0.489

High

835378

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.489

High

835382

INT2
Integrator complex subunit 2

1

2

High-throughput

0.489

High

835385

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.489

High

835388

GHITM
Growth hormone-inducible transmembrane protein

1

4

High-throughput

0.489

High

835392

AT133
Polyamine-transporting ATPase 13A3

1

11

High-throughput

0.489

High

835397

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

1

High-throughput

0.489

High

835404

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

1

High-throughput

0.489

High

835408

T161A
Transmembrane protein 161A

1

2

High-throughput

0.489

High

835416

IPO11
Importin-11

1

7

High-throughput

0.489

High

835419

RAB21
Ras-related protein Rab-21

1

2

High-throughput

0.489

High

835429

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

High-throughput

0.489

High

133457

ACATN
Acetyl-coenzyme A transporter 1

1

1

High-throughput

0.445

High

133732

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.445

High

248567

FADS1
Acyl-CoA

1

2

High-throughput

0.445

High

269524

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.445

High

270626

ATP9A
Probable phospholipid-transporting ATPase IIA

1

2

High-throughput

0.445

High

366474

UROK
Urokinase-type plasminogen activator

1

6

High-throughput

0.445

High

603870

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.445

High

835269

ATM
Serine-protein kinase ATM

1

6

High-throughput

0.445

High

835271

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.426

High

835282

ANO6
Anoctamin-6

1

0

High-throughput

0.426

High

835420

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.426

High

137195

EXOC5
Exocyst complex component 5

1

1

High-throughput

0.407

High

252839

EXOC3
Exocyst complex component 3

1

2

High-throughput

0.407

High

316488

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

1

High-throughput

0.407

High

749596

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

2

High-throughput

0.407

High

773816

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.407

High

814760

CUX1
Homeobox protein cut-like 1

1

1

High-throughput

0.407

High

835265

REEP5
Receptor expression-enhancing protein 5

1

4

High-throughput

0.407

High

835289

RBG1L
Rab GTPase-activating protein 1-like

1

8

High-throughput

0.407

High

835293

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.407

High

835296

MZT2B
Mitotic-spindle organizing protein 2B

1

3

High-throughput

0.407

High

835297

PDXD2
Putative pyridoxal-dependent decarboxylase domain-containing protein 2

1

2

High-throughput

0.407

High

835298

MZT2A
Mitotic-spindle organizing protein 2A

1

3

High-throughput

0.407

High

835305

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

1

High-throughput

0.407

High

835312

WAPL
Wings apart-like protein homolog

1

1

High-throughput

0.407

High

835331

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.407

High

835342

IFT81
Intraflagellar transport protein 81 homolog

1

2

High-throughput

0.407

High

835345

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

7

High-throughput

0.407

High

835413

B4GT7
Beta-1,4-galactosyltransferase 7

1

1

High-throughput

0.407

High

835414

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.407

High

835418

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.407

High

835422

TMX2
Thioredoxin-related transmembrane protein 2

1

2

High-throughput

0.407

High

835424

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

1

High-throughput

0.407

High

211744

ZW10
Centromere/kinetochore protein zw10 homolog

3

0

High-throughput

0.345

High

835319

DAAF5
Dynein axonemal assembly factor 5

3

0

High-throughput

0.345

High

253061

PLIN3
Perilipin-3

2

0

High-throughput

0.328

High

835311

HEAT3
HEAT repeat-containing protein 3

2

0

High-throughput

0.328

High

835315

NOP9
Nucleolar protein 9

2

0

High-throughput

0.328

High

835329

FITM2
Acyl-coenzyme A diphosphatase FITM2

2

0

High-throughput

0.328

High

835358

SAAL1
Protein SAAL1

2

0

High-throughput

0.328

High

835368

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

2

0

High-throughput

0.328

High

835387

TM245
Transmembrane protein 245

2

0

High-throughput

0.328

High

835430

5MP1
eIF5-mimic protein 1

2

0

High-throughput

0.328

High

835364

PIGS
GPI-anchor transamidase component PIGS

2

0

High-throughput

0.313

High

835367

DBND2
Dysbindin domain-containing protein 2

1

0

High-throughput

0.282

High

67061

CO061
Uncharacterized protein C15orf61

1

0

High-throughput

0.279

Low

276951

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.279

Low

301362

WFS1
Wolframin

1

0

High-throughput

0.279

Low

326671

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

578612

FABP4
Fatty acid-binding protein, adipocyte

1

0

High-throughput

0.279

Low

716653

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.279

Low

835262

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.279

Low

835267

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

835272

CND1
Condensin complex subunit 1

1

0

High-throughput

0.279

Low

835304

MMS22
Protein MMS22-like

1

0

High-throughput

0.279

Low

835318

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.279

Low

835340

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

835343

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.279

Low

835374

CHAC1
Glutathione-specific gamma-glutamylcyclotransferase 1

1

0

High-throughput

0.279

Low

835380

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.279

Low

835389

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.279

Low

835396

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

835371

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.249

Low

187480

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.232

Low

214182

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

0

High-throughput

0.232

Low

223806

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.232

Low

298146

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.232

Low

326930

UBE4B
Ubiquitin conjugation factor E4 B

1

0

High-throughput

0.232

Low

835280

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.232

Low

835314

RBM23
Probable RNA-binding protein 23

1

0

High-throughput

0.232

Low

835352

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.232

Low

835386

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.232

Low

835406

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.232

Low

835407

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.232

Low

835426

SNX5
Sorting nexin-5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025