Protein: PJA1
E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)

Gene: PJA1
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q8NG27

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0016567 - protein ubiquitination
GO:0030163 - protein catabolic process
GO:0046872 - metal ion binding
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919792

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.865

High

1245274

PJA1
E3 ubiquitin-protein ligase Praja-1

3

14

Small-scale

0.845

High

895852

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

1245291

NSE3
Non-structural maintenance of chromosomes element 3 homolog

4

11

Small-scale

0.713

High

1245283

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

8

High-throughput

0.670

High

1245320

MAGD1
Melanoma-associated antigen D1

4

11

Small-scale

0.651

High

896337

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

20

Small-scale

0.647

High

932552

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

868267

ATX3
Ataxin-3

3

4

Small-scale

0.646

High

1221582

SMC5
Structural maintenance of chromosomes protein 5

2

3

High-throughput

0.628

High

1245309

DOCK5
Dedicator of cytokinesis protein 5

2

1

High-throughput

0.628

High

1138893

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

476073

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

1245297

RN126
E3 ubiquitin-protein ligase RNF126

1

9

High-throughput

0.618

High

636503

DNJB2
DnaJ homolog subfamily B member 2

2

3

High-throughput

0.611

High

1245286

FAF2
FAS-associated factor 2

3

10

High-throughput

0.609

High

1245287

AP2M1
AP-2 complex subunit mu

3

2

High-throughput

0.609

High

1245295

SMC6
Structural maintenance of chromosomes protein 6

3

5

Small-scale

0.609

High

791784

HD
Huntingtin

2

1

Small-scale

0.584

High

1245284

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.579

High

1245279

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

3

High-throughput

0.574

High

1245290

MAGD4
Melanoma-associated antigen D4

2

11

High-throughput

0.574

High

1245300

LRC27
Leucine-rich repeat-containing protein 27

2

2

High-throughput

0.574

High

1245301

IQCN
IQ domain-containing protein N

2

1

High-throughput

0.574

High

963371

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

9

Small-scale

0.561

High

1080135

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

Small-scale

0.543

High

1245288

OTUB2
Ubiquitin thioesterase OTUB2

2

4

Small-scale

0.543

High

1043974

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.541

High

1035123

MYO9B
Unconventional myosin-IXb

1

2

High-throughput

0.536

High

1245275

ARRD2
Arrestin domain-containing protein 2

1

5

High-throughput

0.536

High

1245278

SSH3
Protein phosphatase Slingshot homolog 3

1

2

High-throughput

0.536

High

1245285

SPSB4
SPRY domain-containing SOCS box protein 4

1

2

High-throughput

0.536

High

1245299

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

1245304

TXNIP
Thioredoxin-interacting protein

1

5

High-throughput

0.536

High

848430

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.515

High

950224

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.515

High

1245316

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

180558

MAGB4
Melanoma-associated antigen B4

1

11

Small-scale

0.501

High

548112

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

1

High-throughput

0.501

High

777055

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

High-throughput

0.501

High

800601

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

11

High-throughput

0.501

High

960391

CDK16
Cyclin-dependent kinase 16

1

1

Small-scale

0.501

High

1245293

TSSK3
Testis-specific serine/threonine-protein kinase 3

1

1

Small-scale

0.501

High

1245296

STAC
SH3 and cysteine-rich domain-containing protein

1

3

Small-scale

0.501

High

1245312

HOME2
Homer protein homolog 2

1

2

Small-scale

0.501

High

1245317

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

High-throughput

0.501

High

1245318

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

High-throughput

0.501

High

735998

ATPG
ATP synthase subunit gamma, mitochondrial

1

1

High-throughput

0.494

High

1059546

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.494

High

1031234

SKP2
S-phase kinase-associated protein 2

1

2

High-throughput

0.489

High

1233845

CBPA6
Carboxypeptidase A6

1

1

High-throughput

0.489

High

1237364

TSYL6
Testis-specific Y-encoded-like protein 6

1

2

High-throughput

0.489

High

1245303

GHC2
Mitochondrial glutamate carrier 2

1

1

High-throughput

0.489

High

317742

STABP
STAM-binding protein

1

0

High-throughput

0.480

High

398277

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

Small-scale

0.480

High

840987

MAP2
Methionine aminopeptidase 2

1

0

Small-scale

0.480

High

899651

FGF12
Fibroblast growth factor 12

1

0

Small-scale

0.480

High

942213

GTF2I
General transcription factor II-I

1

0

Small-scale

0.480

High

981088

LGUL
Lactoylglutathione lyase

1

0

Small-scale

0.480

High

1056799

ESPL1
Separin

1

0

High-throughput

0.480

High

1063503

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.480

High

1245308

RNZ1
Zinc phosphodiesterase ELAC protein 1

1

0

Small-scale

0.480

High

163023

XPO1
Exportin-1

1

2

High-throughput

0.479

High

198936

RFOX2
RNA binding protein fox-1 homolog 2

1

4

High-throughput

0.479

High

336553

SODC
Superoxide dismutase [Cu-Zn]

1

1

Small-scale

0.479

High

726943

FUS
RNA-binding protein FUS

1

5

Small-scale

0.479

High

734701

TRI23
E3 ubiquitin-protein ligase TRIM23

1

9

High-throughput

0.479

High

1086886

DGKD
Diacylglycerol kinase delta

1

1

Small-scale

0.479

High

1100892

MOONR
Protein moonraker

1

2

High-throughput

0.479

High

1245094

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1245282

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

Small-scale

0.479

High

1245307

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1245314

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

741986

TALDO
Transaldolase

1

0

High-throughput

0.458

High

1233306

PNKD
Probable hydrolase PNKD

1

0

High-throughput

0.458

High

197357

SERA
D-3-phosphoglycerate dehydrogenase

1

1

Small-scale

0.457

High

268184

EED
Polycomb protein EED

1

4

Small-scale

0.457

High

432818

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

Small-scale

0.457

High

1021845

ABR
Active breakpoint cluster region-related protein

1

2

Small-scale

0.457

High

1024141

LCP2
Lymphocyte cytosolic protein 2

1

2

Small-scale

0.457

High

1065231

JOS1
Josephin-1

1

4

High-throughput

0.457

High

1088441

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

1

Small-scale

0.457

High

1174024

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

5

High-throughput

0.457

High

1240397

TXND5
Thioredoxin domain-containing protein 5

1

1

Small-scale

0.457

High

1245277

DDX54
ATP-dependent RNA helicase DDX54

1

2

Small-scale

0.457

High

1245289

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.457

High

1245292

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

1

5

Small-scale

0.457

High

1245294

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

12

High-throughput

0.457

High

1245305

ATX3L
Ataxin-3-like protein

1

4

High-throughput

0.457

High

1245315

NAGK
N-acetyl-D-glucosamine kinase

1

2

Small-scale

0.457

High

541075

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

3

High-throughput

0.457

High

1223288

ZN440
Zinc finger protein 440

1

0

High-throughput

0.438

High

341449

FA12
Coagulation factor XII

1

1

High-throughput

0.437

High

632336

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

High-throughput

0.437

High

871867

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

1

High-throughput

0.437

High

1025854

TADBP
TAR DNA-binding protein 43

1

5

Small-scale

0.437

High

1101175

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

1165775

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1245310

MYO10
Unconventional myosin-X

1

1

Small-scale

0.437

High

1245313

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

3

0

Small-scale

0.355

High

1245311

CHRC1
Chromatin accessibility complex protein 1

2

0

High-throughput

0.328

High

335621

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.282

High

1245302

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.282

High

1245306

RIBC2
RIB43A-like with coiled-coils protein 2

1

0

High-throughput

0.282

High

271971

CTAG2
Cancer/testis antigen 2

1

0

High-throughput

0.279

Low

837123

ENTP1
Ectonucleoside triphosphate diphosphohydrolase 1

1

0

High-throughput

0.279

Low

1152361

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.279

Low

362652

A2GL
Leucine-rich alpha-2-glycoprotein

1

0

Small-scale

0.261

Low

378745

KITH
Thymidine kinase, cytosolic

1

0

Small-scale

0.261

Low

1023394

COASY
Bifunctional coenzyme A synthase

1

0

Small-scale

0.261

Low

1083678

TAF9
Transcription initiation factor TFIID subunit 9

1

0

Small-scale

0.261

Low

1156563

TM214
Transmembrane protein 214

1

0

Small-scale

0.261

Low

1236230

NATD1
Protein NATD1

1

0

Small-scale

0.261

Low

1245276

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

Small-scale

0.261

Low

1245281

STAM1
Signal transducing adapter molecule 1

1

0

High-throughput

0.261

Low

1245319

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

Small-scale

0.261

Low

1201320

MORC1
MORC family CW-type zinc finger protein 1

1

0

High-throughput

0.249

Low

1245280

ATLA1
Atlastin-1

1

0

Small-scale

0.249

Low

1245298

SFXN3
Sideroflexin-3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024