HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1217
+	Hs
		1042636 CUL3_HUMAN (1-768): 0: 951: 100.00		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		1041585 CUL3_HUMAN (1-768): 0: 951: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		311540 CUL3_HUMAN (1-768): 0: 951: 100.00		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		1043311 CUL4A_HUMAN (10-768): 0: 791: 38.32		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1041506 CUL2_HUMAN (30-768): 0: 672: 26.17		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1042984 CUL4A_HUMAN (10-768): 0: 791: 38.32		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Mm
		56802 CUL4B_MOUSE (5-768): 0: 779: 36.64		SMC1A_MOUSE (2-1211): 3.28e-79: 286: 16.44