Protein: SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)

Gene: SMRCD, SMARCAD1
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q9H4L7

Gene Ontology (top 5):
GO:0000018 - regulation of DNA recombination
GO:0000729 - DNA double-strand break processing
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1100376

TIF1B
Transcription intermediary factor 1-beta

10

17

Small-scale

0.759

High

608749

DDX5
Probable ATP-dependent RNA helicase DDX5

2

14

Small-scale

0.754

High

1097557

CBX3
Chromobox protein homolog 3

2

20

High-throughput

0.754

High

846672

MSH2
DNA mismatch repair protein Msh2

7

7

Small-scale

0.743

High

1356452

TF3C2
General transcription factor 3C polypeptide 2

2

0

Small-scale

0.716

High

1250412

ZN562
Zinc finger protein 562

3

8

High-throughput

0.667

High

69831

ZN785
Zinc finger protein 785

3

9

High-throughput

0.662

High

1103877

ZN211
Zinc finger protein 211

3

3

High-throughput

0.662

High

1392744

ZN764
Zinc finger protein 764

3

10

High-throughput

0.662

High

1081805

ZN816
Zinc finger protein 816

2

4

High-throughput

0.628

High

1230901

Z324B
Zinc finger protein 324B

2

5

High-throughput

0.628

High

1276064

ZN550
Zinc finger protein 550

2

8

High-throughput

0.628

High

1385016

ZN669
Zinc finger protein 669

2

10

High-throughput

0.628

High

1433864

ZN214
Zinc finger protein 214

2

3

High-throughput

0.628

High

1433874

TF3C3
General transcription factor 3C polypeptide 3

2

12

Small-scale

0.624

High

141660

DDX3X
ATP-dependent RNA helicase DDX3X

1

15

High-throughput

0.618

High

243735

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

16

High-throughput

0.618

High

355295

ACL6A
Actin-like protein 6A

1

20

High-throughput

0.618

High

903482

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

17

High-throughput

0.618

High

981093

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

998804

H31
Histone H3.1

1

20

High-throughput

0.618

High

1017207

H33
Histone H3.3

1

20

High-throughput

0.618

High

1027752

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

16

High-throughput

0.618

High

1062648

DHX9
ATP-dependent RNA helicase A

1

12

High-throughput

0.618

High

1089865

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.618

High

1132976

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

19

High-throughput

0.618

High

1338959

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1369387

DDX17
Probable ATP-dependent RNA helicase DDX17

1

14

High-throughput

0.618

High

1387556

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

14

High-throughput

0.618

High

1414863

WDR18
WD repeat-containing protein 18

1

14

High-throughput

0.618

High

1421313

WDR33
pre-mRNA 3' end processing protein WDR33

1

12

High-throughput

0.618

High

1433849

HELLS
Lymphoid-specific helicase

1

15

High-throughput

0.618

High

1433852

DD19A
ATP-dependent RNA helicase DDX19A

1

19

High-throughput

0.618

High

1433867

RUVB2
RuvB-like 2

1

12

High-throughput

0.618

High

1433868

RUVB1
RuvB-like 1

1

12

High-throughput

0.618

High

913400

MSH6
DNA mismatch repair protein Msh6

2

12

High-throughput

0.611

High

1128680

ZN460
Zinc finger protein 460

2

5

High-throughput

0.611

High

1386440

ZN689
Zinc finger protein 689

2

3

High-throughput

0.611

High

1134724

NUMA1
Nuclear mitotic apparatus protein 1

2

12

High-throughput

0.601

High

1397111

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.585

High

242925

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

373143

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

487752

PARP1
Poly [ADP-ribose] polymerase 1

2

20

High-throughput

0.584

High

1085833

TF3C1
General transcription factor 3C polypeptide 1

2

1

Small-scale

0.584

High

1130186

SMC1A
Structural maintenance of chromosomes protein 1A

2

12

Small-scale

0.584

High

1433863

TF3C4
General transcription factor 3C polypeptide 4

2

2

Small-scale

0.584

High

1433866

SMC3
Structural maintenance of chromosomes protein 3

2

12

Small-scale

0.584

High

1433873

TF3C5
General transcription factor 3C polypeptide 5

2

2

Small-scale

0.584

High

1255536

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

771929

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.541

High

551263

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.536

High

585001

ZNF44
Zinc finger protein 44

1

5

High-throughput

0.536

High

710494

EPHA2
Ephrin type-A receptor 2

1

7

High-throughput

0.536

High

913733

ZN136
Zinc finger protein 136

1

6

High-throughput

0.536

High

1091344

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.536

High

1099780

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

4

High-throughput

0.536

High

1207351

ZN484
Zinc finger protein 484

1

1

High-throughput

0.536

High

1353550

ZN418
Zinc finger protein 418

1

3

High-throughput

0.536

High

1383856

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

1395751

ZN514
Zinc finger protein 514

1

6

High-throughput

0.536

High

1402713

TCPQM
T-complex protein 1 subunit theta-like 2

1

7

High-throughput

0.536

High

1364253

TOPB1
DNA topoisomerase 2-binding protein 1

1

8

Small-scale

0.527

High

785450

RL4
Large ribosomal subunit protein uL4

1

5

High-throughput

0.515

High

964456

SUMO2
Small ubiquitin-related modifier 2

1

16

High-throughput

0.501

High

991429

SUMO1
Small ubiquitin-related modifier 1

1

16

High-throughput

0.501

High

48071

RBM47
RNA-binding protein 47

1

12

High-throughput

0.479

High

129427

MEN1
Menin

1

5

High-throughput

0.479

High

191088

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

214941

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

11

High-throughput

0.479

High

246946

KDM1A
Lysine-specific histone demethylase 1A

1

20

High-throughput

0.479

High

259107

DNJA2
DnaJ homolog subfamily A member 2

1

9

High-throughput

0.479

High

260452

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

274751

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.479

High

282784

E2F6
Transcription factor E2F6

1

8

High-throughput

0.479

High

282904

Z324A
Zinc finger protein 324A

1

6

High-throughput

0.479

High

298449

DNJC8
DnaJ homolog subfamily C member 8

1

6

High-throughput

0.479

High

316992

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.479

High

412610

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

414626

P53
Cellular tumor antigen p53

1

10

High-throughput

0.479

High

542655

TOP2A
DNA topoisomerase 2-alpha

1

12

High-throughput

0.479

High

558401

XRCC6
X-ray repair cross-complementing protein 6

1

10

High-throughput

0.479

High

559496

XRCC5
X-ray repair cross-complementing protein 5

1

10

High-throughput

0.479

High

576551

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

13

High-throughput

0.479

High

589680

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

600376

ZNF24
Zinc finger protein 24

1

9

High-throughput

0.479

High

601981

ZNF8
Zinc finger protein 8

1

8

High-throughput

0.479

High

633339

MSH3
DNA mismatch repair protein Msh3

1

7

High-throughput

0.479

High

634636

LMNB1
Lamin-B1

1

17

High-throughput

0.479

High

665145

COT2
COUP transcription factor 2

1

20

High-throughput

0.479

High

675675

TYY1
Transcriptional repressor protein YY1

1

17

High-throughput

0.479

High

685727

U2AF2
Splicing factor U2AF 65 kDa subunit

1

15

High-throughput

0.479

High

687511

PTBP1
Polypyrimidine tract-binding protein 1

1

13

High-throughput

0.479

High

696501

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

12

High-throughput

0.479

High

718628

CDC27
Cell division cycle protein 27 homolog

1

11

High-throughput

0.479

High

729454

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

16

High-throughput

0.479

High

769172

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

769780

RFC4
Replication factor C subunit 4

1

5

High-throughput

0.479

High

769906

RFC2
Replication factor C subunit 2

1

7

High-throughput

0.479

High

800100

COIL
Coilin

1

7

High-throughput

0.479

High

827490

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.479

High

829151

RFC5
Replication factor C subunit 5

1

5

High-throughput

0.479

High

829272

RFC3
Replication factor C subunit 3

1

5

High-throughput

0.479

High

837841

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

846477

MATR3
Matrin-3

1

8

High-throughput

0.479

High

897395

CDK7
Cyclin-dependent kinase 7

1

2

High-throughput

0.479

High

910688

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

10

High-throughput

0.479

High

965886

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

15

High-throughput

0.479

High

998024

CSK21
Casein kinase II subunit alpha

1

16

High-throughput

0.479

High

1008349

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

High-throughput

0.479

High

1054791

SUH
Recombining binding protein suppressor of hairless

1

9

High-throughput

0.479

High

1055855

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.479

High

1059960

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

High-throughput

0.479

High

1061147

SRSF1
Serine/arginine-rich splicing factor 1

1

14

High-throughput

0.479

High

1065429

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.479

High

1083437

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

9

High-throughput

0.479

High

1086697

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

13

High-throughput

0.479

High

1093047

CDC16
Cell division cycle protein 16 homolog

1

10

High-throughput

0.479

High

1105411

SF3B2
Splicing factor 3B subunit 2

1

2

High-throughput

0.479

High

1107209

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1110078

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1111268

SNW1
SNW domain-containing protein 1

1

7

High-throughput

0.479

High

1114294

CUL3
Cullin-3

1

14

High-throughput

0.479

High

1115428

CUL4B
Cullin-4B

1

14

High-throughput

0.479

High

1120337

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.479

High

1128622

ZN235
Zinc finger protein 235

1

2

High-throughput

0.479

High

1138634

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1144471

NONO
Non-POU domain-containing octamer-binding protein

1

20

High-throughput

0.479

High

1146824

PCBP1
Poly(rC)-binding protein 1

1

11

High-throughput

0.479

High

1148046

SF3B3
Splicing factor 3B subunit 3

1

9

High-throughput

0.479

High

1185837

ZN829
Zinc finger protein 829

1

6

High-throughput

0.479

High

1213148

BEND3
BEN domain-containing protein 3

1

1

High-throughput

0.479

High

1228278

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1246990

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

1276786

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1287987

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

1316587

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

15

High-throughput

0.479

High

1340516

DNJB8
DnaJ homolog subfamily B member 8

1

7

High-throughput

0.479

High

1347553

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

High-throughput

0.479

High

1361232

DNJC9
DnaJ homolog subfamily C member 9

1

5

High-throughput

0.479

High

1368121

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.479

High

1369771

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.479

High

1370705

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

1370749

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

20

High-throughput

0.479

High

1371687

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.479

High

1380010

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

20

High-throughput

0.479

High

1380967

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.479

High

1381444

ZN566
Zinc finger protein 566

1

4

High-throughput

0.479

High

1393952

FUBP3
Far upstream element-binding protein 3

1

17

High-throughput

0.479

High

1396303

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

7

High-throughput

0.479

High

1403019

SIN3A
Paired amphipathic helix protein Sin3a

1

19

High-throughput

0.479

High

1404397

CDC5L
Cell division cycle 5-like protein

1

14

High-throughput

0.479

High

1412179

ZN649
Zinc finger protein 649

1

2

High-throughput

0.479

High

1413341

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

1428619

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

5

High-throughput

0.479

High

1433844

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

5

High-throughput

0.479

High

1433846

DMAP1
DNA methyltransferase 1-associated protein 1

1

1

High-throughput

0.479

High

1433847

ZN302
Zinc finger protein 302

1

4

High-throughput

0.479

High

1433848

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

20

High-throughput

0.479

High

1433850

MDN1
Midasin

1

14

High-throughput

0.479

High

1433853

RBAK
RB-associated KRAB zinc finger protein

1

3

High-throughput

0.479

High

1433854

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

1

High-throughput

0.479

High

1433856

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1433857

CDC23
Cell division cycle protein 23 homolog

1

11

High-throughput

0.479

High

1433858

APC7
Anaphase-promoting complex subunit 7

1

7

High-throughput

0.479

High

1433860

ANC2
Anaphase-promoting complex subunit 2

1

14

High-throughput

0.479

High

1433862

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

2

High-throughput

0.479

High

1433865

PRP19
Pre-mRNA-processing factor 19

1

17

High-throughput

0.479

High

1433870

ZN330
Zinc finger protein 330

1

6

High-throughput

0.479

High

1433871

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.479

High

1433872

SP16H
FACT complex subunit SPT16

1

8

High-throughput

0.479

High

133797

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

345000

WIZ
Protein Wiz

1

0

High-throughput

0.458

High

1128831

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1135813

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1368755

SYMPK
Symplekin

1

0

High-throughput

0.458

High

1430894

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.458

High

1433859

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.458

High

600124

ZNF20
Zinc finger protein 20

1

6

High-throughput

0.445

High

1036615

ZNF45
Zinc finger protein 45

1

2

High-throughput

0.445

High

1159274

ZNF74
Zinc finger protein 74

1

2

High-throughput

0.445

High

1241443

ZFP1
Zinc finger protein 1 homolog

1

7

High-throughput

0.445

High

1273086

ZN627
Zinc finger protein 627

1

8

High-throughput

0.445

High

1357685

ZN480
Zinc finger protein 480

1

4

High-throughput

0.445

High

1367272

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

1398762

ZN578
Zinc finger protein 578

1

4

High-throughput

0.445

High

1412390

ZNF2
Zinc finger protein 2

1

6

High-throughput

0.445

High

1433851

ZFP57
Zinc finger protein 57 homolog

1

6

High-throughput

0.445

High

1433861

ZN223
Zinc finger protein 223

1

5

High-throughput

0.445

High

1433869

ZN337
Zinc finger protein 337

1

2

High-throughput

0.445

High

1091462

ANK3
Ankyrin-3

1

2

High-throughput

0.437

High

1141936

EEA1
Early endosome antigen 1

1

14

High-throughput

0.437

High

1290725

ZCH18
Zinc finger CCCH domain-containing protein 18

1

7

High-throughput

0.437

High

1358108

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.437

High

1433842

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.437

High

1433843

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

1433845

ZFP14
Zinc finger protein 14 homolog

1

0

High-throughput

0.426

High

1399138

CF418
Cilia- and flagella-associated protein 418

1

1

Small-scale

0.417

High

333202

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

3

High-throughput

0.407

High

437794

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

628462

KLK2
Kallikrein-2

1

6

High-throughput

0.407

High

634805

GRAH
Granzyme H

1

6

High-throughput

0.407

High

1366234

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

1433855

DNJB9
DnaJ homolog subfamily B member 9

1

7

High-throughput

0.407

High

1353332

DOK4
Docking protein 4

3

0

High-throughput

0.347

High

1316063

TRM2A
tRNA

2

0

High-throughput

0.328

High

1252973

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

295633

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

342666

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

346779

CER1
Cerberus

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025