HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: STRAP (Q9Y3F4)
Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)
Gene: STRAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 350
+	Hs
		1042655 CUL3_HUMAN (1-768): 0: 951: 100.00		NLE1_HUMAN (126-349): 2.92e-48: 170: 16.42
+	Hs
		152875 CUL3_HUMAN (1-768): 0: 951: 100.00		APAF_HUMAN (15-294): 1.1e-21: 98.6: 25.50
+	Hs
		1042101 CUL3_HUMAN (1-768): 0: 951: 100.00		POC1B_HUMAN (1-89): 3.47e-21: 96.2: 23.60
+	Hs
		903207 CUL3_HUMAN (1-768): 0: 951: 100.00		WDR5_HUMAN (253-346): 5.02e-18: 85.4: 18.09
+	Hs
		1041692 CUL3_HUMAN (1-768): 0: 951: 100.00		SMU1_HUMAN (26-293): 7.19e-16: 80.5: 26.87
+	Hs
		197016 CUL3_HUMAN (1-768): 0: 951: 100.00		PRP4_HUMAN (263-347): 2.41e-15: 78.9: 16.47
+	Hs
		1041647 CUL3_HUMAN (1-768): 0: 951: 100.00		TAF5_HUMAN (12-202): 2.37e-13: 73.2: 29.44
+	Hs
		1032085 CUL3_HUMAN (1-768): 0: 951: 100.00		EIF3I_HUMAN (13-127): 7.75e-09: 58.4: 20.77
+	Hs
		792982 CUL4A_HUMAN (10-768): 0: 791: 38.32		LIS1_HUMAN (181-350): 5.35e-43: 155: 13.87
+	Hs
		1043157 CUL4A_HUMAN (10-768): 0: 791: 38.32		SNR40_HUMAN (1-126): 8.45e-28: 113: 22.96
+	Hs
		1043114 CUL4A_HUMAN (10-768): 0: 791: 38.32		POC1B_HUMAN (1-89): 3.47e-21: 96.2: 23.60
+	Hs
		152876 CUL4B_HUMAN (5-768): 0: 779: 36.77		APAF_HUMAN (15-294): 1.1e-21: 98.6: 25.50
+	Hs
		903208 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5_HUMAN (253-346): 5.02e-18: 85.4: 18.09
+	Hs
		1043469 CUL4B_HUMAN (5-768): 0: 779: 36.77		POC1B_HUMAN (1-89): 3.47e-21: 96.2: 23.60
+	Hs
		1043085 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5B_HUMAN (253-346): 3.5e-16: 80: 18.09
+	Hs
		903209 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5_HUMAN (253-346): 5.02e-18: 85.4: 18.09
+	Hs
		1043385 CUL4B_HUMAN (5-768): 0: 779: 36.77		SMU1_HUMAN (26-293): 7.19e-16: 80.5: 26.87
+	Hs
		1043441 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5B_HUMAN (253-346): 3.5e-16: 80: 18.09
+	Hs
		245601 CUL4B_HUMAN (5-768): 0: 779: 36.77		TBL1X_HUMAN (260-350): 3.92e-13: 72.3: 16.50
+	Hs
		1032086 CUL4A_HUMAN (10-768): 0: 791: 38.32		EIF3I_HUMAN (13-127): 7.75e-09: 58.4: 20.77