HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCA11 (Q8TEB1)
DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23)
Gene: DCAF11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.761

Property	Details
Experiments	27203182, 30945288, 31973889, 32235678, 16964240, 17079684, 21145461, 19295130, 16949367, 28514442, 28453520, 31155351, 33961781, 37689310
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 546
+	Hs
		1043471 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCA11_HUMAN (18-546): 5.28e-125: 379: 100.00
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (168-471): 3.32e-81: 261: 14.59
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (250-544): 2.02e-69: 228: 18.21
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (250-544): 2.02e-69: 228: 18.21
+	Hs
		1043562 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1R_HUMAN (260-546): 4.79e-66: 224: 14.33
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (65-291): 2.25e-44: 162: 12.86
+	Hs
		1043509 CUL4B_HUMAN (10-759): 0: 927: 82.31		SNR40_HUMAN (65-291): 2.25e-44: 162: 12.86
+	Hs
		154680 CUL4A_HUMAN (1-759): 0: 963: 100.00		GNB5_HUMAN (349-534): 4.65e-28: 117: 16.24
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (14-229): 1.27e-26: 114: 10.80
+	Hs
		152876 CUL4B_HUMAN (10-759): 0: 927: 82.31		APAF_HUMAN (72-392): 3.55e-27: 118: 16.31
+	Hs
		1043469 CUL4B_HUMAN (10-759): 0: 927: 82.31		POC1B_HUMAN (14-229): 1.27e-26: 114: 10.80
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (470-546): 1.74e-12: 70.6: 16.67
+	Hs
		1016274 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL3_HUMAN (318-546): 1.07e-21: 101: 11.65
+	Hs
		1043208 CUL4A_HUMAN (1-759): 0: 963: 100.00		SKI8_HUMAN (186-384): 3.11e-09: 60.5: 29.70
+	Hs
		245601 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1X_HUMAN (435-546): 8.58e-14: 76: 11.81
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (470-546): 1.74e-12: 70.6: 16.67
+	Hs
		1043568 CUL4B_HUMAN (10-759): 0: 927: 82.31		SKI8_HUMAN (186-384): 3.11e-09: 60.5: 29.70
+	Hs
		152875 CUL3_HUMAN (32-759): 0: 814: 38.23		APAF_HUMAN (72-392): 3.55e-27: 118: 16.31
+	At
		1114752 CUL4_ARATH (24-759): 0: 861: 57.40		PRL1_ARATH (167-348): 7.99e-12: 69.4: 18.33
+	At
		95048 CUL4_ARATH (24-759): 0: 861: 57.40		KTN82_ARATH (306-525): 1.03e-09: 63.5: 22.27