HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30945288
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 1036
+	Hs
		1043523 CUL4B_HUMAN (10-759): 0: 927: 82.31		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		1042319 CUL3_HUMAN (32-759): 0: 814: 38.23		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		1041151 CUL1_HUMAN (59-759): 0: 745: 30.55		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		1043203 CUL4A_HUMAN (1-759): 0: 963: 100.00		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1043563 CUL4B_HUMAN (10-759): 0: 927: 82.31		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		527987 CUL3_HUMAN (32-759): 0: 814: 38.23		RINI_HUMAN (800-1035): 1.2e-31: 131: 33.90
+	Hs
		1042479 CUL3_HUMAN (32-759): 0: 814: 38.23		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1041938 CUL3_HUMAN (32-759): 0: 814: 38.23		NLRX1_HUMAN (826-1021): 4.41e-13: 75.9: 23.23
+	Hs
		702488 CUL3_HUMAN (32-759): 0: 814: 38.23		C2TA_HUMAN (886-1031): 2.1e-11: 70.5: 23.84
+	Hs
		1041076 CUL1_HUMAN (59-759): 0: 745: 30.55		NLRC5_HUMAN (745-1034): 6.36e-14: 79: 17.47
+	Hs
		702487 CUL1_HUMAN (59-759): 0: 745: 30.55		C2TA_HUMAN (886-1031): 2.1e-11: 70.5: 23.84
+	Hs
		1041384 CUL2_HUMAN (51-759): 0: 710: 27.00		NLRC5_HUMAN (745-1034): 6.36e-14: 79: 17.47