Protein: MRP1
Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)

Gene: MRP1, ABCC1
Organism: Homo sapiens
Interactions: 120
UniProt ID: P33527

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0006691 - leukotriene metabolic process
GO:0006805 - xenobiotic metabolic process
GO:0008559 - ABC-type xenobiotic transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

753779

MRP1
Multidrug resistance-associated protein 1

2

8

Small-scale

0.825

High

753802

CSK21
Casein kinase II subunit alpha

1

3

Small-scale

0.724

High

375230

RASK
GTPase KRas

3

16

High-throughput

0.640

High

609595

LEG3
Galectin-3

2

13

High-throughput

0.601

High

373799

RASN
GTPase NRas

2

16

High-throughput

0.584

High

374427

RASH
GTPase HRas

2

12

High-throughput

0.584

High

753798

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

753804

CAV1
Caveolin-1

2

3

Small-scale

0.584

High

753849

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.575

High

680241

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

5

Small-scale

0.561

High

753788

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

125272

LEG9
Galectin-9

2

13

High-throughput

0.558

High

753853

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.546

High

127288

LEG8
Galectin-8

1

13

High-throughput

0.536

High

669217

NK1R
Substance-P receptor

1

1

High-throughput

0.536

High

753808

CD166
CD166 antigen

1

1

High-throughput

0.536

High

753822

STING
Stimulator of interferon genes protein

1

3

High-throughput

0.536

High

753837

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

1

High-throughput

0.536

High

446693

NPM
Nucleophosmin

1

0

High-throughput

0.518

High

753805

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

0

High-throughput

0.513

High

753855

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.489

High

403865

GCR
Glucocorticoid receptor

1

7

Small-scale

0.481

High

671763

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.481

High

126478

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

133731

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

173868

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.479

High

181687

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.479

High

217886

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

340991

DIRA3
GTP-binding protein Di-Ras3

1

6

High-throughput

0.479

High

411455

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

417281

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

463370

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

466125

RHOC
Rho-related GTP-binding protein RhoC

1

16

High-throughput

0.479

High

540326

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

561916

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

580892

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.479

High

601186

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

603854

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

710088

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

753781

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

753784

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.479

High

753785

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

753787

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

753789

RAC3
Ras-related C3 botulinum toxin substrate 3

1

18

High-throughput

0.479

High

753790

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

753791

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.479

High

753793

RHOA
Transforming protein RhoA

1

18

High-throughput

0.479

High

753794

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

753796

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

753797

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.479

High

753800

RAC1
Ras-related C3 botulinum toxin substrate 1

1

18

High-throughput

0.479

High

753801

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

753803

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.479

High

753811

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.479

High

753812

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

753814

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

753818

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

753820

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

753825

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

753827

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

753833

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

753836

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

753838

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

753843

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

753844

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

753845

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

753852

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

189434

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

293280

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

327178

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

692866

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

715449

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

753780

BASI
Basigin

1

0

High-throughput

0.458

High

753782

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

753799

H4
Histone H4

1

0

High-throughput

0.458

High

753813

OCLN
Occludin

1

0

High-throughput

0.458

High

753821

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.458

High

753835

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

753841

DERL1
Derlin-1

1

0

High-throughput

0.458

High

104111

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.445

High

182478

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.445

High

255993

S19A2
Thiamine transporter 1

1

2

High-throughput

0.445

High

538732

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

4

High-throughput

0.445

High

669301

ACKR3
Atypical chemokine receptor 3

1

9

High-throughput

0.445

High

703993

5HT1E
5-hydroxytryptamine receptor 1E

1

2

High-throughput

0.445

High

753783

CXCR3
C-X-C chemokine receptor type 3

1

7

High-throughput

0.445

High

753786

CCR9
C-C chemokine receptor type 9

1

7

High-throughput

0.445

High

753792

CXCR4
C-X-C chemokine receptor type 4

1

8

High-throughput

0.445

High

753810

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.445

High

753816

NIPA3
Magnesium transporter NIPA3

1

2

High-throughput

0.445

High

753817

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

4

High-throughput

0.445

High

753826

LAT4
Large neutral amino acids transporter small subunit 4

1

2

High-throughput

0.445

High

753830

S7A14
Solute carrier family 7 member 14

1

2

High-throughput

0.445

High

753832

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.445

High

753839

OPALI
Opalin

1

1

High-throughput

0.445

High

753840

S1PR3
Sphingosine 1-phosphate receptor 3

1

7

High-throughput

0.445

High

753846

S39A2
Zinc transporter ZIP2

1

2

High-throughput

0.445

High

753806

TRAF3
TNF receptor-associated factor 3

1

1

High-throughput

0.439

High

753795

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

753819

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

753823

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

753824

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.437

High

753834

ESR2
Estrogen receptor beta

1

7

High-throughput

0.437

High

753851

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

753854

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

379907

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

753815

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

753831

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.426

High

753848

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

753850

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.426

High

753856

FADS3
Fatty acid desaturase 3

1

0

High-throughput

0.426

High

753809

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.407

High

753828

ZNT7
Zinc transporter 7

1

4

High-throughput

0.407

High

753829

DNJB8
DnaJ homolog subfamily B member 8

1

2

High-throughput

0.407

High

753842

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.324

High

519059

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

753807

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

753847

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

469462

SYPH
Synaptophysin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025