HitPredict

Interactor 1: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Interactor 2: PLXA1 (Q9UIW2)
Plexin-A1 (Semaphorin receptor NOV)
Gene: PLXNA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1447 Hs			1 1896
+	Hs
		850468 PTC1_HUMAN (1-1447): 0: 1579: 100.00		PLXA3_HUMAN (39-1896): 0: 2343: 67.15
+	Hs
		165196 PTC1_HUMAN (1-1447): 0: 1579: 100.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		1044473 PTC1_HUMAN (1-1447): 0: 1579: 100.00		PLXD1_HUMAN (45-1893): 0: 1846: 31.33
+	Hs
		1027961 PTC1_HUMAN (1-1447): 0: 1579: 100.00		SEM3B_HUMAN (16-547): 2.46e-133: 437: 17.50
+	Hs
		1044443 PTC1_HUMAN (1-1447): 0: 1579: 100.00		SEM4B_HUMAN (23-769): 2.82e-124: 414: 16.45
+	Hs
		1044436 PTC1_HUMAN (1-1447): 0: 1579: 100.00		SEM6A_HUMAN (6-549): 2.71e-119: 406: 16.36
+	Hs
		1044423 PTC1_HUMAN (1-1447): 0: 1579: 100.00		SEM3C_HUMAN (40-545): 1.06e-121: 404: 15.43
+	Hs
		981868 PTC1_HUMAN (1-1447): 0: 1579: 100.00		RON_HUMAN (815-1212): 5.65e-85: 310: 25.24
+	Dm
		55132 PTC_DROME (48-1283): 0: 993: 38.23		A1ZAF5_DROME (44-541): 9.95e-34: 143: 18.06