HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: ECT2 (Q9H8V3)
Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
Gene: ECT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31586073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2472 Hs			1 914
+	Hs
		164666 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		963418 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		974147 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1068667 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1329039 SPTN4_HUMAN (961-2371): 1.09e-21: 105: 13.80		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1045423 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ITSN1_HUMAN (402-782): 1.02e-76: 276: 18.14
+	Hs
		1333811 MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		506843 SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		521615 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		211665 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		963335 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ITSN1_HUMAN (402-782): 1.02e-76: 276: 18.14
+	Hs
		974083 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		ITSN1_HUMAN (402-782): 1.02e-76: 276: 18.14
+	Hs
		1068638 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		FGD4_HUMAN (312-858): 1.12e-81: 281: 18.53
+	Hs
		1068677 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		ARHG4_HUMAN (350-880): 1.39e-79: 274: 17.20
+	Hs
		548710 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		VAV_HUMAN (390-707): 1.61e-76: 269: 21.82
+	Hs
		1068630 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		Q96D37_HUMAN (390-707): 1.05e-76: 268: 21.82
+	Hs
		1273273 CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94		ARHG2_HUMAN (249-775): 2e-83: 291: 15.02
+	Hs
		962561 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		ECT2L_HUMAN (453-721): 2.8e-23: 108: 28.93
+	Hs
		1021851 CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94		ABR_HUMAN (463-641): 7.42e-16: 84.3: 30.27