HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: TNIP2 (Q8NFZ5)
TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein)
Gene: TNIP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

The method score is based on:

Property	Details
Experiments	27609421, 29084252, 14743216, 33438746
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, tandem affinity purification
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0006954 - inflammatory response GO:0019901 - protein kinase binding and 4 others more... GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070498 - interleukin-1-mediated signaling pathway GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	551
Hs

1	429

Service provided by Combinatics, Japan

Last updated: 11Aug2025