HitPredict

Interactor 1: DX39B (Q13838)
Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)
Gene: DDX39B

Interactor 2: THOC6 (Q86W42)
THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)
Gene: THOC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	27684187, 35271311, 15998806, 17190602
Identification Methods	affinity chromatography technology, biochemical, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000346 - transcription export complex GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006406 - mRNA export from nucleus and 2 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 341
+	Hs
		181721 DDX3Y_HUMAN (2-423): 1.77e-153: 451: 28.44		POC1A_HUMAN (114-338): 1.1e-57: 193: 13.54
+	Hs
		1271679 DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06		NLE1_HUMAN (2-329): 1.88e-73: 236: 11.81
+	Dm
		1099539 DX39B_DROME (1-425): 1.1e-136: 400: 84.27		THOC6_DROME (18-341): 9.09e-73: 231: 26.99
+	Hs
		197017 DX39B_HUMAN (1-428): 6.01e-135: 395: 100.00		PRP4_HUMAN (2-244): 2.6e-52: 182: 12.65
+	Sc
		744704 SUB2_YEAST (5-424): 2.73e-178: 506: 62.59		TAF5_YEAST (160-330): 7.47e-12: 68.5: 10.47
+	Hs
		236218 DX39B_HUMAN (1-428): 6.01e-135: 395: 100.00		PRP17_HUMAN (1-284): 9.1e-50: 176: 8.67
+	Hs
		1271621 DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06		SNR40_HUMAN (1-152): 5.89e-29: 116: 14.65
+	Hs
		571547 DDX5_HUMAN (6-421): 4.17e-133: 397: 25.00		SNR40_HUMAN (1-152): 5.89e-29: 116: 14.65
+	Hs
		1271615 DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06		FBXW7_HUMAN (1-149): 4.03e-22: 99.3: 7.38
+	Hs
		920963 DX39B_HUMAN (1-428): 6.01e-135: 395: 100.00		GBB1_HUMAN (117-339): 5.07e-23: 99.7: 12.04
+	Hs
		1046069 DX39B_HUMAN (1-428): 6.01e-135: 395: 100.00		A16L1_HUMAN (65-330): 1.22e-16: 82.9: 15.39
+	Hs
		117194 DX39A_HUMAN (1-428): 3.89e-128: 378: 89.95		FBXW7_HUMAN (1-149): 4.03e-22: 99.3: 7.38
+	Mm
		1207848 DX39B_MOUSE (1-428): 9.81e-135: 395: 99.53		A16L1_MOUSE (13-330): 1.42e-15: 79.4: 16.31
+	Hs
		134154 DDX3X_HUMAN (3-423): 4.76e-124: 375: 27.84		FBXW7_HUMAN (1-149): 4.03e-22: 99.3: 7.38
+	Hs
		903410 DDX17_HUMAN (6-423): 6.26e-132: 398: 25.06		WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76
+	Hs
		571382 DDX5_HUMAN (6-421): 4.17e-133: 397: 25.00		WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76
+	Hs
		903213 DX39B_HUMAN (1-428): 6.01e-135: 395: 100.00		WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76
+	Mm
		1207640 DX39A_MOUSE (1-428): 1.49e-129: 382: 90.42		A16L1_MOUSE (13-330): 1.42e-15: 79.4: 16.31
+	Hs
		117161 DX39A_HUMAN (1-428): 3.89e-128: 378: 89.95		A16L1_HUMAN (65-330): 1.22e-16: 82.9: 15.39
+	Hs
		133956 DDX3X_HUMAN (3-423): 4.76e-124: 375: 27.84		WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76