Protein: RRP45
Exosome complex component RRP45 (Ribosomal RNA-processing protein 45)

Gene: RRP45
Organism: Saccharomyces cerevisiae S288C
Interactions: 103
UniProt ID: Q05636

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

863136

RRP41
Exosome complex component SKI6

14

20

Small-scale

0.986

High

923984

CSL4
Exosome complex component CSL4

12

12

Small-scale

0.978

High

1051718

RRP44
Exosome complex exonuclease DIS3

11

19

Small-scale

0.977

High

918892

RRP46
Exosome complex component RRP46

9

20

Small-scale

0.970

High

672947

RRP43
Exosome complex component RRP43

8

2

Small-scale

0.967

High

804749

RRP4
Exosome complex component RRP4

7

20

Small-scale

0.962

High

1051719

RRP40
Exosome complex component RRP40

6

12

Small-scale

0.945

High

871124

MTR3
Exosome complex component MTR3

5

2

Small-scale

0.922

High

1051726

RRP6
Exosome complex exonuclease RRP6

12

12

Small-scale

0.757

High

1051729

RRP42
Exosome complex component RRP42

6

17

Small-scale

0.730

High

1046031

DHR1
Probable ATP-dependent RNA helicase DHR1

6

3

High-throughput

0.729

High

844613

UTP10
U3 small nucleolar RNA-associated protein 10

5

2

High-throughput

0.712

High

922954

MPP6
M-phase phosphoprotein 6 homolog

4

2

Small-scale

0.696

High

609081

SKI3
Superkiller protein 3

4

4

High-throughput

0.694

High

763626

UTP20
U3 small nucleolar RNA-associated protein 20

4

2

High-throughput

0.691

High

1051720

SKI7
Superkiller protein 7

8

7

Small-scale

0.683

High

804958

LRP1
Exosome complex protein LRP1

4

2

Small-scale

0.683

High

918822

UTP22
U3 small nucleolar RNA-associated protein 22

4

3

High-throughput

0.678

High

1051707

RRP45
Exosome complex component RRP45

1

17

High-throughput

0.665

High

798309

ENP1
Essential nuclear protein 1

3

2

High-throughput

0.640

High

763855

SKI2
Antiviral helicase SKI2

4

16

High-throughput

0.633

High

1050160

RRP5
rRNA biogenesis protein RRP5

3

8

High-throughput

0.633

High

1039041

IMA1
Importin subunit alpha

2

2

High-throughput

0.588

High

1028610

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

0

High-throughput

0.585

High

677563

KRR1
KRR1 small subunit processome component

2

2

High-throughput

0.584

High

864518

MTR4
ATP-dependent RNA helicase DOB1

2

16

Small-scale

0.584

High

1046788

UTP14
U3 small nucleolar RNA-associated protein 14

2

3

High-throughput

0.584

High

1051713

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

527684

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

546286

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.552

High

792949

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.541

High

921611

NRD1
Protein NRD1

1

1

Small-scale

0.536

High

644990

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.493

High

735161

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.493

High

1051724

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.480

High

673227

RRP7
Ribosomal RNA-processing protein 7

1

2

High-throughput

0.479

High

678459

PWP2
Periodic tryptophan protein 2

1

12

High-throughput

0.479

High

708194

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

754332

DCA13
Protein SOF1

1

9

High-throughput

0.479

High

758407

UTP11
U3 small nucleolar RNA-associated protein 11

1

2

High-throughput

0.479

High

776648

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.479

High

806572

UTP9
U3 small nucleolar RNA-associated protein 9

1

2

High-throughput

0.479

High

817630

UTP7
U3 small nucleolar RNA-associated protein 7

1

6

High-throughput

0.479

High

823384

UTP18
U3 small nucleolar RNA-associated protein 18

1

3

High-throughput

0.479

High

826211

FAF1
Protein FAF1

1

2

High-throughput

0.479

High

865171

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

871055

NOL10
Ribosome biogenesis protein ENP2

1

1

High-throughput

0.479

High

919170

UTP8
U3 small nucleolar RNA-associated protein 8

1

2

High-throughput

0.479

High

924631

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

925195

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

1036408

UTP6
U3 small nucleolar RNA-associated protein 6

1

2

High-throughput

0.479

High

1039850

UTP17
NET1-associated nuclear protein 1

1

14

High-throughput

0.479

High

1045104

UTP5
U3 small nucleolar RNA-associated protein 5

1

11

High-throughput

0.479

High

1046249

UTP15
U3 small nucleolar RNA-associated protein 15

1

8

High-throughput

0.479

High

1051158

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

1051709

UTP13
U3 small nucleolar RNA-associated protein 13

1

16

High-throughput

0.479

High

1051710

UTP21
U3 small nucleolar RNA-associated protein 21

1

14

High-throughput

0.479

High

1051711

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

2

High-throughput

0.479

High

1051712

RRP9
Ribosomal RNA-processing protein 9

1

12

High-throughput

0.479

High

1051714

BFR2
Protein BFR2

1

2

High-throughput

0.479

High

1051716

UTP4
U3 small nucleolar RNA-associated protein 4

1

10

High-throughput

0.479

High

1051717

RCL1
rRNA processing protein RCL1

1

2

High-throughput

0.479

High

1051721

UTP16
U3 small nucleolar RNA-associated protein 16

1

2

High-throughput

0.479

High

1051722

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

1051723

FCF2
rRNA-processing protein FCF2

1

3

High-throughput

0.479

High

1051725

SAS10
Something about silencing protein 10

1

3

High-throughput

0.479

High

1051727

YRA1
RNA annealing protein YRA1

1

3

Small-scale

0.479

High

1051728

UTP12
U3 small nucleolar RNA-associated protein 12

1

15

High-throughput

0.479

High

1051730

NOP56
Nucleolar protein 56

1

7

High-throughput

0.479

High

1051731

NOP58
Nucleolar protein 58

1

7

High-throughput

0.479

High

1051732

RRP12
Ribosomal RNA-processing protein 12

1

2

High-throughput

0.479

High

1051733

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

893225

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

3

High-throughput

0.470

High

852602

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

1051734

PNO1
Pre-rRNA-processing protein PNO1

1

0

Small-scale

0.458

High

403658

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

525160

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

597276

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

727313

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

742399

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

804460

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

811399

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

819803

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

503852

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

511296

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

590726

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

453792

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.407

High

510823

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.407

High

580075

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

592504

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

626888

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.407

High

752735

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

816410

HSP7E
Heat shock protein SSC3, mitochondrial

1

6

High-throughput

0.407

High

893159

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

3

High-throughput

0.407

High

1051708

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

11

High-throughput

0.407

High

757823

YBF5
Deoxyribonuclease Tat-D

1

0

High-throughput

0.269

Low

866171

ENT3
Epsin-3

1

0

High-throughput

0.269

Low

370481

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

0

High-throughput

0.249

Low

605927

HPR1
THO complex subunit HPR1

1

0

Small-scale

0.249

Low

694173

CDC15
Cell division control protein 15

1

0

High-throughput

0.249

Low

863737

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

1051715

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025