HitPredict

Interactor 1: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	31578224
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0030424 - axon GO:0030509 - BMP signaling pathway GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 757
+	Hs
		738413 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Mm
		1143778 TGFR2_MOUSE (8-504): 1.23e-137: 427: 30.19		SMUF1_MOUSE (1-757): 0: 855: 95.24
+	Hs
		122298 BMR1B_HUMAN (21-509): 5.73e-120: 379: 27.24		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		740065 TGFR2_HUMAN (8-521): 1.09e-118: 378: 29.66		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		981139 ACVR1_HUMAN (53-512): 1.91e-117: 372: 29.27		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		738579 TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		740064 TGFR2_HUMAN (8-521): 1.09e-118: 378: 29.66		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Mm
		56831 TGFR1_MOUSE (59-504): 2.76e-112: 358: 28.72		SMUF2_MOUSE (1-757): 0: 795: 71.30
+	Hs
		738578 TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		125195 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		337392 ABL1_HUMAN (166-1016): 1.93e-137: 444: 15.47		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		740040 TGFR2_HUMAN (8-521): 1.09e-118: 378: 29.66		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		738569 TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125199 TGFR2_HUMAN (8-521): 1.09e-118: 378: 29.66		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		738312 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		337496 ABL1_HUMAN (166-1016): 1.93e-137: 444: 15.47		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		738509 TGFR1_HUMAN (59-504): 1.1e-110: 354: 29.30		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		337535 ABL1_HUMAN (166-1016): 1.93e-137: 444: 15.47		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		738403 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Dm
		1279501 Q95SI0_DROME (51-506): 3.35e-114: 364: 29.65		SMUF1_DROME (5-293): 2.09e-29: 127: 34.24