HitPredict

Interactor 1: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Interactor 2: PFD5 (Q99471)
Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1)
Gene: PFDN5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 743 Hs			1 154
+	Hs
		983558 GBB1_HUMAN (447-739): 3.4e-90: 287: 18.54		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1061838 TLE5_HUMAN (1-185): 2.39e-91: 285: 62.89		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		163651 GNB5_HUMAN (446-739): 1.51e-86: 280: 20.46		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1334160 POC1A_HUMAN (490-742): 3.98e-75: 250: 16.02		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1404671 GBB4_HUMAN (484-742): 1e-57: 201: 16.05		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		965177 WDR5_HUMAN (628-742): 1.7e-35: 139: 21.37		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1349429 POC1B_HUMAN (301-514): 4.42e-16: 83.7: 8.51		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1387515 SNR40_HUMAN (509-740): 1.7e-14: 77.8: 24.28		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1202566 Q59G26_HUMAN (659-742): 4.16e-14: 76: 18.82		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		1232392 Q6FHM2_HUMAN (659-742): 2.09e-13: 74.1: 17.65		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00
+	Hs
		984245 GBB2_HUMAN (659-742): 2.09e-13: 74.1: 17.65		PFD5_HUMAN (1-154): 2.04e-60: 185: 100.00