Protein: GNB5
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)

Gene: GNB5
Organism: Homo sapiens
Interactions: 59
UniProt ID: O14775

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163622

RGS7
Regulator of G-protein signaling 7

9

13

Small-scale

0.754

High

163627

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

5

20

Small-scale

0.713

High

163621

RGS6
Regulator of G-protein signaling 6

4

13

Small-scale

0.696

High

163636

PHLP
Phosducin-like protein

4

15

Small-scale

0.694

High

163606

RGS11
Regulator of G-protein signaling 11

3

13

Small-scale

0.676

High

163605

RGS9
Regulator of G-protein signaling 9

3

13

Small-scale

0.667

High

163619

TCPG
T-complex protein 1 subunit gamma

3

20

High-throughput

0.667

High

163649

CSN5
COP9 signalosome complex subunit 5

3

6

High-throughput

0.667

High

163651

PFD5
Prefoldin subunit 5

3

11

High-throughput

0.656

High

163655

GBG13

2

6

Small-scale

0.629

High

163632

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.628

High

163630

GBG5

2

20

Small-scale

0.614

High

163657

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

20

High-throughput

0.601

High

163629

GBG3

2

20

Small-scale

0.594

High

163643

R7BP
Regulator of G-protein signaling 7-binding protein

2

1

Small-scale

0.584

High

163644

PR40B
Pre-mRNA-processing factor 40 homolog B

2

10

High-throughput

0.574

High

163613

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.541

High

163620

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.541

High

163616

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

163628

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

18

High-throughput

0.536

High

163633

FOXK2
Forkhead box protein K2

1

5

High-throughput

0.536

High

163639

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

15

High-throughput

0.536

High

163653

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

163624

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.518

High

163625

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.518

High

163611

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

163615

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.508

High

163631

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

163641

T22D1
TSC22 domain family protein 1

1

13

High-throughput

0.508

High

163608

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

163638

E2F2
Transcription factor E2F2

1

2

High-throughput

0.494

High

163602

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.486

High

163603

GBG7

1

20

Small-scale

0.481

High

163609

DRD2
D(2) dopamine receptor

1

7

Small-scale

0.481

High

163623

GBG4

1

20

Small-scale

0.481

High

163610

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.479

High

163612

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

7

Small-scale

0.479

High

163614

STIP1
Stress-induced-phosphoprotein 1

1

13

High-throughput

0.479

High

163617

MTOR
Serine/threonine-protein kinase mTOR

1

9

Small-scale

0.479

High

163618

TCPE
T-complex protein 1 subunit epsilon

1

20

Small-scale

0.479

High

163626

MLF1
Myeloid leukemia factor 1

1

7

High-throughput

0.479

High

163634

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

163635

CTBP1
C-terminal-binding protein 1

1

7

High-throughput

0.479

High

163637

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

163642

MLF2
Myeloid leukemia factor 2

1

7

High-throughput

0.479

High

163646

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

163647

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

3

High-throughput

0.479

High

163648

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.479

High

163652

DNJC7
DnaJ homolog subfamily C member 7

1

15

High-throughput

0.479

High

163654

AASD1
Alanyl-tRNA editing protein Aarsd1

1

4

High-throughput

0.479

High

163656

PFD2
Prefoldin subunit 2

1

8

High-throughput

0.479

High

163658

NUDC
Nuclear migration protein nudC

1

18

High-throughput

0.479

High

63717

PSD1
PH and SEC7 domain-containing protein 1

1

2

High-throughput

0.457

High

163640

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

16

High-throughput

0.457

High

163604

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.438

High

163607

NOE2
Noelin-2

1

0

High-throughput

0.438

High

104838

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

163645

Q6PK50
HSP90AB1 protein

1

11

High-throughput

0.437

High

163650

Q96BE0
Heat shock cognate 71 kDa protein

1

17

High-throughput

0.437

High


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Last updated: 11Aug2025