HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.754

The method score is based on:

Property Details
Experiments 35820905, 21903422, 21200404, 29125880, 32511263, 34239064, 36056146, 19380491, 24706939, 19153231, 16177806
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0031966 - mitochondrial membrane
GO:0032481 - positive regulation of type I interferon production
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0051091 - positive regulation of DNA-binding transcription factor activity
GO:0051607 - defense response to virus
and 2 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 716
Hs

1 540
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+ Mm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024