HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: NEDD8 (Q15843)
Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)
Gene: NEDD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 81
+	Hs
		728152 AKT1_HUMAN (172-582): 8.17e-152: 447: 36.85		RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14
+	Hs
		728153 AKT1_HUMAN (172-582): 8.17e-152: 447: 36.85		RL40_HUMAN (1-76): 3.81e-33: 112: 57.90
+	Hs
		507093 AKT2_HUMAN (148-582): 3.96e-153: 450: 36.56		UBB_HUMAN (1-76): 2.41e-30: 107: 57.90
+	Hs
		507092 AKT1_HUMAN (172-582): 8.17e-152: 447: 36.85		UBB_HUMAN (1-76): 2.41e-30: 107: 57.90
+	Hs
		986995 KPCE_HUMAN (6-191): 1.17e-23: 107: 21.00		RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14
+	Hs
		436647 KPCB_HUMAN (85-187): 8.52e-22: 101: 27.18		RL40_HUMAN (1-76): 3.81e-33: 112: 57.90
+	Hs
		1034997 KPCE_HUMAN (6-191): 1.17e-23: 107: 21.00		NEDD8_HUMAN (1-81): 2.08e-30: 103: 100.00
+	Hs
		436588 KPCB_HUMAN (85-187): 8.52e-22: 101: 27.18		UBB_HUMAN (1-76): 2.41e-30: 107: 57.90