HitPredict

Interactor 1: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0045296 - cadherin binding GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 550 Hs			1 1025
+	Hs
		1052264 SRC8_HUMAN (1-550): 0: 559: 100.00		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		724825 SRC8_HUMAN (1-550): 0: 559: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1052202 SRC8_HUMAN (1-550): 0: 559: 100.00		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		1167445 PACN2_HUMAN (176-550): 4.93e-40: 153: 15.37		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		1167415 PACN1_HUMAN (241-549): 2.37e-31: 128: 16.86		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		1355219 PACN2_HUMAN (176-550): 4.93e-40: 153: 15.37		SWP70_HUMAN (370-824): 7.27e-58: 212: 19.22
+	Hs
		1329256 PACN2_HUMAN (176-550): 4.93e-40: 153: 15.37		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		1315994 PACN1_HUMAN (241-549): 2.37e-31: 128: 16.86		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		1153451 PACN2_HUMAN (176-550): 4.93e-40: 153: 15.37		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		148746 MYO1E_HUMAN (165-549): 3.1e-44: 170: 15.01		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		1045526 SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		148786 SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		235554 VINEX_HUMAN (254-546): 4.43e-13: 73.9: 13.51		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		724801 MYO1E_HUMAN (165-549): 3.1e-44: 170: 15.01		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		235528 VINEX_HUMAN (254-546): 4.43e-13: 73.9: 13.51		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		1059994 LASP1_HUMAN (358-547): 4.29e-13: 71.4: 22.93		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		724817 SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		522612 SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12		MYH7_HUMAN (101-931): 7.33e-17: 88.6: 10.36
+	Hs
		1045418 SPTN1_HUMAN (213-549): 1.51e-33: 138: 14.12		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		1078856 ITSN1_HUMAN (165-548): 1.66e-14: 78.9: 11.99		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89