Protein: SOX4
Transcription factor SOX-4

Gene: SOX4
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q06945

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1024016

TFAM
Transcription factor A, mitochondrial

1

19

High-throughput

0.618

High

1057466

PB1
Protein polybromo-1

1

20

High-throughput

0.618

High

413691

P53
Cellular tumor antigen p53

1

12

Small-scale

0.589

High

140238

SDCB1
Syntenin-1

1

5

Small-scale

0.561

High

285643

BAF
Barrier-to-autointegration factor

1

2

Small-scale

0.552

High

993520

UBC9
SUMO-conjugating enzyme UBC9

1

11

Small-scale

0.552

High

227859

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.536

High

1057453

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.515

High

1057461

ACTBL
Beta-actin-like protein 2

1

5

High-throughput

0.515

High

1041980

LMNB2
Lamin-B2

1

19

Small-scale

0.504

High

162936

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

170102

AURKA
Aurora kinase A

1

14

High-throughput

0.501

High

371849

MYC
Myc proto-oncogene protein

1

18

High-throughput

0.501

High

375442

RASK
GTPase KRas

1

5

High-throughput

0.501

High

624499

WT1
Wilms tumor protein

1

20

High-throughput

0.501

High

637888

NF1
Neurofibromin

1

4

High-throughput

0.501

High

728190

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

High-throughput

0.501

High

767177

MERL
Merlin

1

14

High-throughput

0.501

High

842735

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

15

High-throughput

0.501

High

903333

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

High-throughput

0.501

High

1057458

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.501

High

1057469

TSC1
Hamartin

1

14

High-throughput

0.501

High

1057474

NSD3
Histone-lysine N-methyltransferase NSD3

1

18

High-throughput

0.501

High

1057478

DACH1
Dachshund homolog 1

1

3

High-throughput

0.501

High

1057479

FZR1
Fizzy-related protein homolog

1

19

High-throughput

0.501

High

957340

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.500

High

1057482

PDIP2
Polymerase delta-interacting protein 2

1

1

High-throughput

0.500

High

1057483

STRAP
Serine-threonine kinase receptor-associated protein

1

20

High-throughput

0.500

High

288084

FOXH1
Forkhead box protein H1

1

20

Small-scale

0.481

High

294779

CAN15
Calpain-15

1

12

Small-scale

0.481

High

1057462

CTR9
RNA polymerase-associated protein CTR9 homolog

1

12

Small-scale

0.481

High

1057472

MNT
Max-binding protein MNT

1

20

Small-scale

0.481

High

175016

SC16A
Protein transport protein Sec16A

1

17

High-throughput

0.479

High

183634

RT12
Small ribosomal subunit protein uS12m

1

4

High-throughput

0.479

High

243928

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

3

High-throughput

0.479

High

284941

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

20

High-throughput

0.479

High

660043

COF1
Cofilin-1

1

1

High-throughput

0.479

High

662563

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

20

Small-scale

0.479

High

701804

ABCD3
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.479

High

729542

CASPE
Caspase-14

1

2

High-throughput

0.479

High

755692

MCM4
DNA replication licensing factor MCM4

1

8

High-throughput

0.479

High

814795

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.479

High

888001

MCM2
DNA replication licensing factor MCM2

1

10

High-throughput

0.479

High

907395

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

1057454

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

4

High-throughput

0.479

High

1057455

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.479

High

1057456

MCM6
DNA replication licensing factor MCM6

1

10

High-throughput

0.479

High

1057457

TAF5
Transcription initiation factor TFIID subunit 5

1

20

Small-scale

0.479

High

1057459

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

1

High-throughput

0.479

High

1057460

FIL1L
Filamin A-interacting protein 1-like

1

10

High-throughput

0.479

High

1057465

TAD2B
Transcriptional adapter 2-beta

1

11

High-throughput

0.479

High

1057470

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

1057471

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

1057473

PDIP3
Polymerase delta-interacting protein 3

1

7

High-throughput

0.479

High

1057475

GTPB4
GTP-binding protein 4

1

6

High-throughput

0.479

High

1057476

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.479

High

1057477

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

2

High-throughput

0.479

High

1057481

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

8

Small-scale

0.479

High

1057484

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

High-throughput

0.479

High

258451

EDF1
Endothelial differentiation-related factor 1

1

0

Small-scale

0.460

High

420279

IGF1
Insulin-like growth factor 1

1

0

Small-scale

0.460

High

622498

TNNI3
Troponin I, cardiac muscle

1

0

Small-scale

0.460

High

902337

SCNNG
Epithelial sodium channel subunit gamma

1

0

Small-scale

0.460

High

1057464

NANGN
NANOG neighbor homeobox

1

0

Small-scale

0.460

High

1028164

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1057468

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1057463

RHOU
Rho-related GTP-binding protein RhoU

1

18

High-throughput

0.457

High

208128

PLXB1
Plexin-B1

1

2

Small-scale

0.439

High

626052

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

3

Small-scale

0.439

High

387649

APOC3
Apolipoprotein C-III

1

0

Small-scale

0.288

High

63795

RGSL
Regulator of G-protein signaling protein-like

1

0

Small-scale

0.251

Low

1057467

PLD3
5'-3' exonuclease PLD3

1

0

Small-scale

0.251

Low

1057480

MINP1
Multiple inositol polyphosphate phosphatase 1

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025