Protein: HM20A
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)

Gene: HM20A, HMG20A
Organism: Homo sapiens
Interactions: 236
UniProt ID: Q9NP66

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0006325 - chromatin organization
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1445897

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

7

20

Small-scale

0.969

High

1445888

HM20A
High mobility group protein 20A

6

18

Small-scale

0.951

High

1368138

HDAC2
Histone deacetylase 2

7

20

Small-scale

0.752

High

1110104

HDAC1
Histone deacetylase 1

7

20

High-throughput

0.751

High

246971

KDM1A
Lysine-specific histone demethylase 1A

7

20

Small-scale

0.748

High

911119

IMA1
Importin subunit alpha-1

1

10

High-throughput

0.740

High

262437

DTNB
Dystrobrevin beta

5

2

Small-scale

0.728

High

1384449

PF21A
PHD finger protein 21A

5

20

Small-scale

0.720

High

1445910

RCOR1
REST corepressor 1

5

20

Small-scale

0.718

High

1005828

RPP30
Ribonuclease P protein subunit p30

4

1

High-throughput

0.698

High

320359

PHF14
PHD finger protein 14

4

8

High-throughput

0.694

High

350142

SNAI1
Zinc finger protein SNAI1

4

10

Small-scale

0.694

High

1381868

H2B1A
Histone H2B type 1-A

4

20

High-throughput

0.691

High

1416178

SCNM1
Sodium channel modifier 1

4

0

High-throughput

0.668

High

1382636

MGN2
Protein mago nashi homolog 2

3

3

High-throughput

0.667

High

1394526

PAWR
PRKC apoptosis WT1 regulator protein

3

0

High-throughput

0.646

High

426964

FGF1
Fibroblast growth factor 1

3

0

High-throughput

0.638

High

1385443

SYTL4
Synaptotagmin-like protein 4

4

1

High-throughput

0.637

High

1353334

DOK4
Docking protein 4

4

4

High-throughput

0.630

High

502140

H2AZ
Histone H2A.Z

2

20

High-throughput

0.628

High

587225

ITF2
Transcription factor 4

2

6

High-throughput

0.628

High

1445904

SMBT1
Scm-like with four MBT domains protein 1

2

6

High-throughput

0.628

High

240002

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.618

High

776133

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.618

High

776255

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.618

High

872767

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.618

High

942124

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.618

High

1130666

GSE1
Genetic suppressor element 1

3

2

High-throughput

0.616

High

1445898

RCOR3
REST corepressor 3

3

20

High-throughput

0.616

High

1445917

DTNA
Dystrobrevin alpha

3

2

Small-scale

0.610

High

297870

PIAS2
E3 SUMO-protein ligase PIAS2

2

5

High-throughput

0.606

High

407537

K2C1
Keratin, type II cytoskeletal 1

2

4

High-throughput

0.606

High

633800

PSB1
Proteasome subunit beta type-1

2

8

High-throughput

0.606

High

682106

RBTN1
Rhombotin-1

2

20

High-throughput

0.606

High

1274007

OLIG3
Oligodendrocyte transcription factor 3

2

5

High-throughput

0.606

High

1397451

CI072
Guanine nucleotide exchange factor C9orf72

2

1

High-throughput

0.606

High

1414786

TRAF4
TNF receptor-associated factor 4

2

14

High-throughput

0.606

High

1419353

BACH2
Transcription regulator protein BACH2

2

19

High-throughput

0.606

High

1445889

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

8

High-throughput

0.606

High

1445893

FX4L1
Forkhead box protein D4-like 1

2

20

High-throughput

0.606

High

1445916

ARIP4
Helicase ARIP4

2

20

High-throughput

0.606

High

1445890

ZC4H2
Zinc finger C4H2 domain-containing protein

2

0

High-throughput

0.602

High

1106716

SMAD4
Mothers against decapentaplegic homolog 4

2

6

Small-scale

0.600

High

143279

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

474314

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

980371

H4
Histone H4

2

14

High-throughput

0.584

High

981113

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

998833

H31
Histone H3.1

2

20

High-throughput

0.584

High

1017227

H33
Histone H3.3

2

20

High-throughput

0.584

High

1088042

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1402313

RANB9
Ran-binding protein 9

2

16

Small-scale

0.584

High

844010

HD
Huntingtin

1

4

High-throughput

0.582

High

1385053

CHP3
Calcineurin B homologous protein 3

1

2

High-throughput

0.582

High

1332945

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

0

High-throughput

0.580

High

1392921

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1415507

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1417708

DGC6L
Protein DGCR6L

2

0

High-throughput

0.580

High

1395353

CC136
Coiled-coil domain-containing protein 136

2

11

High-throughput

0.578

High

276348

HMMR
Hyaluronan mediated motility receptor

2

10

High-throughput

0.574

High

1104806

SNTA1
Alpha-1-syntrophin

2

4

High-throughput

0.574

High

1104880

SNTB2
Beta-2-syntrophin

2

4

High-throughput

0.574

High

1118454

SNTB1
Beta-1-syntrophin

2

3

High-throughput

0.574

High

1241042

L2GL2
LLGL scribble cell polarity complex component 2

2

7

High-throughput

0.574

High

1315925

RCOR2
REST corepressor 2

2

20

High-throughput

0.574

High

1445919

CEP83
Centrosomal protein of 83 kDa

2

11

High-throughput

0.574

High

774116

ADDA
Alpha-adducin

1

7

High-throughput

0.573

High

1278932

BRAP
BRCA1-associated protein

2

8

Small-scale

0.572

High

397000

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

353568

AGR2
Anterior gradient protein 2 homolog

2

2

High-throughput

0.553

High

868260

SYQ
Glutamine--tRNA ligase

2

2

High-throughput

0.553

High

907196

SUOX
Sulfite oxidase, mitochondrial

2

2

High-throughput

0.553

High

965584

NTF2
Nuclear transport factor 2

2

5

High-throughput

0.553

High

1116699

RIN1
Ras and Rab interactor 1

2

4

High-throughput

0.553

High

1295377

GPSM1
G-protein-signaling modulator 1

2

14

High-throughput

0.553

High

1330087

USBP1
Harmonin-binding protein USHBP1

2

8

High-throughput

0.553

High

1348522

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.553

High

1386885

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.553

High

1415235

KIFC3
Kinesin-like protein KIFC3

2

4

High-throughput

0.553

High

1445891

PICK1
PRKCA-binding protein

2

1

High-throughput

0.553

High

1445892

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.553

High

297032

CCNK
Cyclin-K

1

6

High-throughput

0.541

High

900175

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

943318

RBM11
Splicing regulator RBM11

1

9

High-throughput

0.541

High

1116034

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.541

High

1445912

TF2AY
TFIIA-alpha and beta-like factor

1

1

High-throughput

0.541

High

1445918

RBM7
RNA-binding protein 7

1

11

High-throughput

0.541

High

74615

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

17

High-throughput

0.536

High

316999

MTA2
Metastasis-associated protein MTA2

1

20

High-throughput

0.536

High

384556

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.536

High

487780

PARP1
Poly [ADP-ribose] polymerase 1

1

20

High-throughput

0.536

High

502549

H2A1
Histone H2A type 1

1

20

High-throughput

0.536

High

542232

TOP1
DNA topoisomerase 1

1

6

High-throughput

0.536

High

572229

TRI27
Zinc finger protein RFP

1

6

High-throughput

0.536

High

591848

H2AX
Histone H2AX

1

20

High-throughput

0.536

High

601868

HMGA1
High mobility group protein HMG-I/HMG-Y

1

4

High-throughput

0.536

High

729466

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

19

High-throughput

0.536

High

998046

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

1066505

RBBP4
Histone-binding protein RBBP4

1

20

High-throughput

0.536

High

1111437

DGKZ
Diacylglycerol kinase zeta

1

2

High-throughput

0.536

High

1159015

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.536

High

1162898

H2A2C
Histone H2A type 2-C

1

20

High-throughput

0.536

High

1163224

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1210536

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.536

High

1232733

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.536

High

1250670

BCOR
BCL-6 corepressor

1

20

High-throughput

0.536

High

1279172

RAI1
Retinoic acid-induced protein 1

1

20

High-throughput

0.536

High

1295309

P66A
Transcriptional repressor p66-alpha

1

10

High-throughput

0.536

High

1361018

P66B
Transcriptional repressor p66-beta

1

10

High-throughput

0.536

High

1431059

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1445900

MBD2
Methyl-CpG-binding domain protein 2

1

6

High-throughput

0.536

High

1445903

TCF20
Transcription factor 20

1

20

High-throughput

0.536

High

337616

FMNL1
Formin-like protein 1

1

1

High-throughput

0.523

High

880206

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.523

High

1397863

CFA53
Cilia- and flagella-associated protein 53

1

5

High-throughput

0.523

High

1445901

MO4L1
Mortality factor 4-like protein 1

1

1

High-throughput

0.515

High

155359

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.513

High

1055975

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.513

High

1417005

HEMGN
Hemogen

1

1

Small-scale

0.504

High

1445914

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

532988

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.489

High

1368492

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

1445909

DCTN4
Dynactin subunit 4

1

1

High-throughput

0.481

High

132771

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

16

High-throughput

0.479

High

181569

TBXT
T-box transcription factor T

1

15

High-throughput

0.479

High

187189

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.479

High

192965

CLOCK
Circadian locomoter output cycles protein kaput

1

17

High-throughput

0.479

High

217205

MS18B
Protein Mis18-beta

1

1

High-throughput

0.479

High

225120

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

226605

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

260487

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

289177

PRDM1
PR domain zinc finger protein 1

1

9

High-throughput

0.479

High

316038

RECQ4
ATP-dependent DNA helicase Q4

1

16

High-throughput

0.479

High

331342

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.479

High

340411

YETS4
YEATS domain-containing protein 4

1

3

High-throughput

0.479

High

373215

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

406677

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

419219

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.479

High

540955

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

590497

GATA1
Erythroid transcription factor

1

19

High-throughput

0.479

High

607125

CEBPB
CCAAT/enhancer-binding protein beta

1

20

High-throughput

0.479

High

662284

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

662505

GATA2
Endothelial transcription factor GATA-2

1

19

High-throughput

0.479

High

662656

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

19

High-throughput

0.479

High

685355

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

703204

TEAD1
Transcriptional enhancer factor TEF-1

1

3

High-throughput

0.479

High

725325

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

754993

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

775917

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

883696

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

905170

MECP2
Methyl-CpG-binding protein 2

1

18

High-throughput

0.479

High

907589

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

959666

MAX
Protein max

1

20

High-throughput

0.479

High

1056654

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

1091160

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

1091350

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.479

High

1137535

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1141322

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1145389

RNPS1
RNA-binding protein with serine-rich domain 1

1

19

High-throughput

0.479

High

1155797

EZH2
Histone-lysine N-methyltransferase EZH2

1

17

High-throughput

0.479

High

1160897

TBR1
T-box brain protein 1

1

15

High-throughput

0.479

High

1243055

PKN3
Serine/threonine-protein kinase N3

1

8

High-throughput

0.479

High

1279309

I2BP2
Interferon regulatory factor 2-binding protein 2

1

14

Small-scale

0.479

High

1313448

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

1322546

MIER1
Mesoderm induction early response protein 1

1

20

High-throughput

0.479

High

1328966

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

9

High-throughput

0.479

High

1350722

CCHCR
Coiled-coil alpha-helical rod protein 1

1

6

High-throughput

0.479

High

1351169

SP7
Transcription factor Sp7

1

16

High-throughput

0.479

High

1363987

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1367345

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1380178

FBXW7
F-box/WD repeat-containing protein 7

1

15

High-throughput

0.479

High

1387578

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.479

High

1399359

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

7

High-throughput

0.479

High

1405441

FEV
Protein FEV

1

18

High-throughput

0.479

High

1406926

NP1L4
Nucleosome assembly protein 1-like 4

1

7

High-throughput

0.479

High

1413345

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.479

High

1417483

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1420502

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.479

High

1445862

GCM1
Chorion-specific transcription factor GCMa

1

3

High-throughput

0.479

High

1445905

XPO7
Exportin-7

1

14

High-throughput

0.479

High

1445908

RABX5
Rab5 GDP/GTP exchange factor

1

1

High-throughput

0.479

High

1445911

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

20

High-throughput

0.479

High

1445913

ASF1A
Histone chaperone ASF1A

1

2

High-throughput

0.479

High

1445915

ZN330
Zinc finger protein 330

1

4

High-throughput

0.479

High

1445920

SP16H
FACT complex subunit SPT16

1

11

High-throughput

0.479

High

1064030

ECHP
Peroxisomal bifunctional enzyme

1

3

High-throughput

0.470

High

1156600

CCDC6
Coiled-coil domain-containing protein 6

1

11

High-throughput

0.470

High

1413271

TCHP
Trichoplein keratin filament-binding protein

1

4

High-throughput

0.470

High

128481

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.458

High

270276

MTG16
Protein CBFA2T3

1

0

Small-scale

0.458

High

503669

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

1187989

GON4L
GON-4-like protein

1

0

High-throughput

0.458

High

1239950

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1389079

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1056984

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

985346

RL10A
Large ribosomal subunit protein uL1

1

7

High-throughput

0.445

High

1445902

DAXX
Death domain-associated protein 6

1

2

High-throughput

0.445

High

220807

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.439

High

1445896

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

High-throughput

0.438

High

165470

RGRF2
Ras-specific guanine nucleotide-releasing factor 2

1

2

High-throughput

0.437

High

938509

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.437

High

1122447

GIT2
ARF GTPase-activating protein GIT2

1

6

High-throughput

0.437

High

1196324

GRAP1
GRIP1-associated protein 1

1

7

High-throughput

0.437

High

1200076

EIPR1
EARP and GARP complex-interacting protein 1

1

20

High-throughput

0.437

High

1201159

CCD93
Coiled-coil domain-containing protein 93

1

3

High-throughput

0.437

High

1237927

PHLB3
Pleckstrin homology-like domain family B member 3

1

6

High-throughput

0.437

High

1294576

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

6

High-throughput

0.437

High

1348332

GOGA5
Golgin subfamily A member 5

1

11

High-throughput

0.437

High

1419601

NUF2
Kinetochore protein Nuf2

1

9

High-throughput

0.437

High

1445895

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.437

High

1445899

HECW2
E3 ubiquitin-protein ligase HECW2

1

15

High-throughput

0.437

High

516588

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

3438

A0A0S2Z528
Proline-serine-threonine phosphatase interacting protein 1 isoform 3

1

3

High-throughput

0.417

High

3458

A0A0S2Z5D5
Dynactin subunit 4

1

1

High-throughput

0.417

High

1411413

CAB45
45 kDa calcium-binding protein

1

2

High-throughput

0.407

High

789672

HPCL1
Hippocalcin-like protein 1

2

0

High-throughput

0.337

High

1307852

TPPC5
Trafficking protein particle complex subunit 5

2

0

High-throughput

0.316

High

1347090

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.316

High

1391897

CEP95
Centrosomal protein of 95 kDa

2

0

High-throughput

0.316

High

1397248

LURA1
Leucine rich adaptor protein 1

2

0

High-throughput

0.316

High

1445894

T11L1
T-complex protein 11-like protein 1

2

0

High-throughput

0.316

High

1445907

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

0

High-throughput

0.316

High

1431237

RSPH9
Radial spoke head protein 9 homolog

1

0

High-throughput

0.299

High

570991

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.279

Low

1231290

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.279

Low

1006306

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.268

Low

1119000

BYST
Bystin

1

0

High-throughput

0.268

Low

1310955

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.268

Low

85313

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

1217286

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

1226534

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1278451

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.249

Low

1394934

VPS50
Syndetin

1

0

High-throughput

0.249

Low

1439060

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1445773

TUFT1
Tuftelin

1

0

High-throughput

0.249

Low

1445906

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025