HitPredict

Interactor 1: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	28205554, 20562859
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 1164
+	Hs
		724826 BECN1_HUMAN (1-450): 0: 645: 100.00		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		551703 BECN1_HUMAN (1-450): 0: 645: 100.00		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		725162 BECN1_HUMAN (1-450): 0: 645: 100.00		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43