Protein: NSD3
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)

Gene: NSD3
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q9BZ95

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998773

H31
Histone H3.1

6

20

Small-scale

0.934

High

980278

H4
Histone H4

2

9

Small-scale

0.768

High

277813

H2AY
Core histone macro-H2A.1

2

18

Small-scale

0.754

High

981070

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

260413

BRD4
Bromodomain-containing protein 4

9

20

Small-scale

0.752

High

1162034

H31T
Histone H3.1t

1

20

Small-scale

0.710

High

1163187

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

853399

CBX5
Chromobox protein homolog 5

3

20

High-throughput

0.669

High

1193379

GLYR1
Cytokine-like nuclear factor N-PAC

1

7

High-throughput

0.656

High

1239475

H3C
Histone H3.3C

1

20

High-throughput

0.656

High

674318

BRD2
Bromodomain-containing protein 2

3

20

High-throughput

0.656

High

396879

ESR1
Estrogen receptor

3

20

High-throughput

0.654

High

1419513

NSD3
Histone-lysine N-methyltransferase NSD3

1

16

High-throughput

0.647

High

754975

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

883678

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

1017187

H33
Histone H3.3

1

20

High-throughput

0.618

High

1255410

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

1338944

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1387546

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.618

High

1097543

CBX3
Chromobox protein homolog 3

2

20

High-throughput

0.614

High

1333170

KDM1B
Lysine-specific histone demethylase 2

2

6

Small-scale

0.611

High

386194

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

17

High-throughput

0.601

High

373079

MYC
Myc proto-oncogene protein

2

10

Small-scale

0.595

High

641010

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

2

High-throughput

0.584

High

1141291

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

1055965

RAD51
DNA repair protein RAD51 homolog 1

1

3

High-throughput

0.582

High

1102251

ATM
Serine-protein kinase ATM

1

6

High-throughput

0.582

High

335504

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.573

High

478340

HXC4
Homeobox protein Hox-C4

1

6

High-throughput

0.573

High

833180

MNDA
Myeloid cell nuclear differentiation antigen

1

4

High-throughput

0.573

High

1419520

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.573

High

355028

CHK2
Serine/threonine-protein kinase Chk2

1

2

High-throughput

0.541

High

728417

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

High-throughput

0.541

High

842854

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

12

High-throughput

0.541

High

1040075

PAX2
Paired box protein Pax-2

1

7

High-throughput

0.541

High

1132428

CASP8
Caspase-8

1

2

High-throughput

0.541

High

1380845

TRI63
E3 ubiquitin-protein ligase TRIM63

1

14

High-throughput

0.541

High

1419283

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

340398

YETS4
YEATS domain-containing protein 4

1

4

High-throughput

0.536

High

974279

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

3

High-throughput

0.536

High

1014195

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.536

High

1062634

DHX9
ATP-dependent RNA helicase A

1

7

High-throughput

0.536

High

186225

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.518

High

376906

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.518

High

984531

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.515

High

374904

RASH
GTPase HRas

1

8

High-throughput

0.515

High

1241382

Q6P2C6
MLLT6 protein

1

11

High-throughput

0.515

High

1279733

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

1419527

V9HWG0
Epididymis luminal protein 25

1

20

High-throughput

0.515

High

832568

ETV3
ETS translocation variant 3

1

12

High-throughput

0.508

High

993735

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.508

High

1037355

H11
Histone H1.1

1

17

High-throughput

0.508

High

1398111

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

5

High-throughput

0.508

High

474261

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.501

High

833583

SOX3
Transcription factor SOX-3

1

18

High-throughput

0.501

High

1057474

SOX4
Transcription factor SOX-4

1

18

High-throughput

0.501

High

1150250

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

1419514

GLIS2
Zinc finger protein GLIS2

1

4

High-throughput

0.501

High

294890

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

14

High-throughput

0.494

High

648654

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.494

High

1351966

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.494

High

1408111

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.486

High

936572

AF17
Protein AF-17

1

10

High-throughput

0.481

High

1331734

ZN557
Zinc finger protein 557

1

5

High-throughput

0.481

High

162967

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

587521

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.480

High

1419522

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.480

High

129397

MEN1
Menin

1

4

High-throughput

0.479

High

191078

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

251651

CCNT1
Cyclin-T1

1

3

Small-scale

0.479

High

254425

CC14B
Dual specificity protein phosphatase CDC14B

1

12

High-throughput

0.479

High

274050

CREST
Calcium-responsive transactivator

1

10

Small-scale

0.479

High

331294

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

487721

PARP1
Poly [ADP-ribose] polymerase 1

1

17

High-throughput

0.479

High

634614

LMNB1
Lamin-B1

1

16

High-throughput

0.479

High

644218

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

2

High-throughput

0.479

High

697244

APEX1
DNA repair nuclease/redox regulator APEX1

1

5

High-throughput

0.479

High

711740

RABP2
Cellular retinoic acid-binding protein 2

1

2

High-throughput

0.479

High

800084

COIL
Coilin

1

3

High-throughput

0.479

High

862425

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

903248

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

Small-scale

0.479

High

903474

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

905111

MECP2
Methyl-CpG-binding protein 2

1

13

High-throughput

0.479

High

979209

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

984962

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

1049744

1433F
14-3-3 protein eta

1

12

High-throughput

0.479

High

1086812

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

Small-scale

0.479

High

1114216

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1196909

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

Small-scale

0.479

High

1201960

BRDT
Bromodomain testis-specific protein

1

20

High-throughput

0.479

High

1276747

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1290963

TAXB1
Tax1-binding protein 1

1

11

High-throughput

0.479

High

1313408

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1332710

ZBT38
Zinc finger and BTB domain-containing protein 38

1

5

Small-scale

0.479

High

1338700

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

16

Small-scale

0.479

High

1352730

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1357467

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

Small-scale

0.479

High

1367203

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1370700

SMRC1
SWI/SNF complex subunit SMARCC1

1

12

Small-scale

0.479

High

1419515

BRD9
Bromodomain-containing protein 9

1

18

Small-scale

0.479

High

1419516

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

Small-scale

0.479

High

1419517

ANLN
Anillin

1

1

High-throughput

0.479

High

1419518

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

6

High-throughput

0.479

High

1419521

NUP50
Nuclear pore complex protein Nup50

1

5

High-throughput

0.479

High

1419523

ASF1A
Histone chaperone ASF1A

1

4

High-throughput

0.479

High

1419525

ZN330
Zinc finger protein 330

1

5

High-throughput

0.479

High

539006

EPB41
Protein 4.1

1

1

High-throughput

0.470

High

650392

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.470

High

789010

TGFR2
TGF-beta receptor type-2

1

1

High-throughput

0.470

High

1121196

SEPT6
Septin-6

1

5

High-throughput

0.464

High

533754

CLUS
Clusterin

1

1

High-throughput

0.457

High

1229226

ZNF57
Zinc finger protein 57

1

2

High-throughput

0.457

High

106604

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

732394

PRDX2
Peroxiredoxin-2

1

6

High-throughput

0.437

High

1308374

CCD71
Coiled-coil domain-containing protein 71

1

3

Small-scale

0.437

High

1419519

CRNN
Cornulin

1

7

Small-scale

0.437

High

1419524

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.279

Low

1419526

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1398831

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025