HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: RPRD2 (Q5VT52)
Regulation of nuclear pre-mRNA domain-containing protein 2
Gene: RPRD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29656893
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 1461
+	Hs
		1056898 MDC1_HUMAN (1-2089): 0: 665: 100.00		ARI1B_HUMAN (345-1272): 1.03e-38: 160: 14.79
+	Hs
		1056827 MDC1_HUMAN (1-2089): 0: 665: 100.00		MDC1_HUMAN (193-1458): 7.63e-14: 79.4: 9.95
+	Hs
		1056876 MDC1_HUMAN (1-2089): 0: 665: 100.00		MICA3_HUMAN (472-1064): 6.17e-10: 66.5: 12.81
+	Hs
		1019030 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		ARI1B_HUMAN (345-1272): 1.03e-38: 160: 14.79
+	Mm
		1157867 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2C_MOUSE (522-1454): 1.9e-44: 180: 14.88
+	Hs
		577600 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SON_HUMAN (145-1398): 1.82e-27: 124: 11.90
+	Hs
		1018956 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		MDC1_HUMAN (193-1458): 7.63e-14: 79.4: 9.95
+	Hs
		1018957 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		NCOA6_HUMAN (387-1460): 1.11e-10: 69: 8.82
+	Hs
		1057810 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		NCOA6_HUMAN (387-1460): 1.11e-10: 69: 8.82
+	Hs
		801143 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MDC1_HUMAN (193-1458): 7.63e-14: 79.4: 9.95
+	Hs
		1056872 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		MDC1_HUMAN (193-1458): 7.63e-14: 79.4: 9.95
+	Hs
		1057766 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		NCOA6_HUMAN (387-1460): 1.11e-10: 69: 8.82
+	Hs
		1173188 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2C_HUMAN (419-1318): 5.75e-09: 63.4: 11.04
+	Hs
		1303336 MUC4_HUMAN (143-1535): 2.62e-31: 137: 12.14		MUC4_HUMAN (168-811): 1.42e-17: 91.9: 12.25
+	Hs
		554259 MUC1_HUMAN (762-1525): 1.68e-11: 72: 18.23		MUC1_HUMAN (695-1453): 3.72e-35: 148: 12.34
+	Dm
		113976 M9PB30_DROME (131-695): 8.03e-11: 70.2: 6.81		M9PB30_DROME (148-859): 3.59e-20: 100: 9.43
+	Mm
		1351630 PCLO_MOUSE (75-1749): 3.3e-11: 71.5: 7.45		PCLO_MOUSE (930-1458): 2.14e-11: 71.3: 8.70