HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: EMSY (Q7Z589)
BRCA2-interacting transcriptional repressor EMSY
Gene: EMSY

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29656893
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 1322
+	Hs
		1056827 MDC1_HUMAN (1-2089): 0: 665: 100.00		MDC1_HUMAN (94-1250): 3.69e-25: 116: 10.96
+	Hs
		1019006 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		EMSY_HUMAN (1-1322): 5.68e-132: 441: 100.00
+	Hs
		1018956 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		MDC1_HUMAN (94-1250): 3.69e-25: 116: 10.96
+	Hs
		801143 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MDC1_HUMAN (94-1250): 3.69e-25: 116: 10.96
+	Hs
		1302939 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		MINT_HUMAN (72-1304): 8.31e-15: 82.4: 10.57
+	Hs
		801326 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MINT_HUMAN (72-1304): 8.31e-15: 82.4: 10.57
+	Hs
		1056872 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		MDC1_HUMAN (94-1250): 3.69e-25: 116: 10.96
+	Hs
		152608 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		KMT2D_HUMAN (261-1253): 1.13e-12: 75.2: 7.65
+	Hs
		1173188 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2C_HUMAN (136-1005): 1.04e-12: 75.6: 6.91
+	Hs
		152660 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2D_HUMAN (261-1253): 1.13e-12: 75.2: 7.65
+	Mm
		1157866 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2D_MOUSE (94-1013): 5.18e-13: 76.4: 9.20
+	Hs
		1173208 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		P121A_HUMAN (148-938): 9.85e-10: 65.6: 12.45
+	Dm
		65570 FUTSC_DROME (102-1944): 3.69e-41: 170: 8.41		A8JNM5_DROME (113-1127): 2.73e-11: 71: 14.96
+	Hs
		1264771 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		TITIN_HUMAN (94-1299): 1.78e-13: 78.2: 9.72
+	Hs
		1303336 MUC4_HUMAN (143-1535): 2.62e-31: 137: 12.14		MUC4_HUMAN (75-477): 6.47e-14: 79.4: 11.34
+	Dm
		113976 M9PB30_DROME (131-695): 8.03e-11: 70.2: 6.81		M9PB30_DROME (664-1317): 8.4e-18: 92.6: 9.55
+	Mm
		1351630 PCLO_MOUSE (75-1749): 3.3e-11: 71.5: 7.45		PCLO_MOUSE (784-1313): 3.46e-11: 70.6: 8.46