HitPredict

Interactor 1: LTBP1 (Q14766)
Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)
Gene: LTBP1

Interactor 2: VWCE (Q96DN2)
von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)
Gene: VWCE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1721 Hs			1 955
+	Hs
		980375 LTBP1_HUMAN (1-1721): 0: 643: 100.00		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		1059042 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21
+	Hs
		1059044 LTBP1_HUMAN (1-1721): 0: 643: 100.00		NOTC3_HUMAN (1-511): 7.1e-24: 111: 14.21
+	Hs
		1059014 LTBP1_HUMAN (1-1721): 0: 643: 100.00		LTBP1_HUMAN (141-573): 5e-21: 101: 20.00
+	Hs
		1016949 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBLN3_HUMAN (46-217): 4.18e-18: 90.6: 25.26
+	Hs
		724370 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBN2_HUMAN (3-483): 4.74e-15: 82.4: 12.34
+	Hs
		957267 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBLN2_HUMAN (181-300): 7.32e-10: 65.2: 25.64
+	Hs
		724341 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBN1_HUMAN (125-262): 3.99e-09: 63.2: 37.67
+	Hs
		980413 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		NPNT_HUMAN (43-279): 6.48e-55: 202: 30.49
+	Dm
		422709 NOTCH_DROME (287-1427): 3.09e-70: 264: 13.21		NOTCH_DROME (1-566): 1.91e-28: 126: 12.46
+	Hs
		980578 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		JAG2_HUMAN (209-851): 1.57e-28: 125: 10.62
+	Hs
		980576 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		NOTC3_HUMAN (1-511): 7.1e-24: 111: 14.21
+	Hs
		612843 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		FBLN1_HUMAN (149-534): 1.88e-20: 99.1: 18.80
+	Hs
		944119 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		JAG1_HUMAN (472-832): 1.91e-17: 90.2: 10.33
+	Hs
		980450 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		BMPER_HUMAN (372-564): 7.24e-16: 84.5: 25.00
+	Hs
		724367 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		FBN2_HUMAN (3-483): 4.74e-15: 82.4: 12.34
+	Hs
		804213 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		NOTC1_HUMAN (6-391): 9.43e-14: 78.2: 11.19
+	Dm
		90684 NOTCH_DROME (287-1427): 3.09e-70: 264: 13.21		E1JHA6_DROME (369-843): 1.02e-13: 78.2: 10.76
+	Dm
		422951 NOTCH_DROME (287-1427): 3.09e-70: 264: 13.21		Q9W2H2_DROME (371-501): 1.72e-12: 73.7: 23.08