Protein: EHMT2
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Protein G9a)

Gene: EHMT2
Organism: Mus musculus
Interactions: 69
UniProt ID: Q9Z148

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0002039 - p53 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1362837

EED
Polycomb protein EED

2

17

Small-scale

0.754

High

1204127

EHMT1
Histone-lysine N-methyltransferase EHMT1

2

15

Small-scale

0.737

High

1013727

TNIK
Traf2 and NCK-interacting protein kinase

1

14

High-throughput

0.691

High

1000276

EZH1
Histone-lysine N-methyltransferase EZH1

1

18

Small-scale

0.665

High

1222454

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.665

High

1017384

H33
Histone H3.3

1

20

Small-scale

0.647

High

476252

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.646

High

1189666

MPP8
M-phase phosphoprotein 8

1

18

Small-scale

0.618

High

1221419

CSK21
Casein kinase II subunit alpha

1

6

Small-scale

0.618

High

1222085

RBBP4
Histone-binding protein RBBP4

1

7

Small-scale

0.618

High

1353944

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

10

Small-scale

0.618

High

1424454

PALLD
Palladin

1

6

Small-scale

0.618

High

1491904

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

16

Small-scale

0.618

High

1281988

SUZ12
Polycomb protein Suz12

1

0

Small-scale

0.586

High

1014280

CBX1
Chromobox protein homolog 1

2

20

Small-scale

0.584

High

312434

DNM3A
DNA

1

8

Small-scale

0.578

High

312447

DNM3B
DNA

1

8

Small-scale

0.578

High

117098

J3QPN0
Zinc finger protein 518B

1

6

Small-scale

0.561

High

834654

CD27
CD27 antigen

1

6

Small-scale

0.553

High

1059047

NFE2
Transcription factor NF-E2 45 kDa subunit

1

1

Small-scale

0.536

High

1283232

NANOG
Homeobox protein NANOG

1

14

High-throughput

0.536

High

1424245

Q9DCC5
Cbx3 protein

2

20

Small-scale

0.533

High

669440

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

6

High-throughput

0.528

High

59173

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

Small-scale

0.501

High

1423839

DNM3L
DNA

1

8

Small-scale

0.501

High

63122

A5D6Q2
Nuclear receptor coactivator 3

1

6

High-throughput

0.481

High

73077

ZN462
Zinc finger protein 462

1

4

Small-scale

0.479

High

73954

Z518A
Zinc finger protein 518A

1

6

Small-scale

0.479

High

97785

ZN568
Zinc finger protein 568

1

1

Small-scale

0.479

High

98260

E9QA23
Zinc finger protein 644

1

9

Small-scale

0.479

High

266711

GFI1B
Zinc finger protein Gfi-1b

1

9

Small-scale

0.479

High

312031

WIZ
Protein Wiz

1

10

Small-scale

0.479

High

484847

HXA9
Homeobox protein Hox-A9

1

7

Small-scale

0.479

High

568906

DNMT1
DNA

1

14

Small-scale

0.479

High

688522

TWST1
Twist-related protein 1

1

7

High-throughput

0.479

High

947462

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

Small-scale

0.479

High

1036640

MTF2
Metal-response element-binding transcription factor 2

1

4

Small-scale

0.479

High

1189908

MIER2
Mesoderm induction early response protein 2

1

13

Small-scale

0.479

High

1221278

PRDM1
PR domain zinc finger protein 1

1

2

Small-scale

0.479

High

1222189

NCOA2
Nuclear receptor coactivator 2

1

5

Small-scale

0.479

High

1222921

ERR2
Steroid hormone receptor ERR2

1

16

High-throughput

0.479

High

1223244

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.479

High

1225273

TFE3
Transcription factor E3

1

4

High-throughput

0.479

High

1242751

MBTD1
MBT domain-containing protein 1

1

5

Small-scale

0.479

High

1253338

LCOR
Ligand-dependent corepressor

1

2

Small-scale

0.479

High

1253552

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

1274657

MCAF1
Activating transcription factor 7-interacting protein 1

1

14

Small-scale

0.479

High

1296933

HIRP3
HIRA-interacting protein 3

1

2

Small-scale

0.479

High

1297635

POGZ
Pogo transposable element with ZNF domain

1

6

Small-scale

0.479

High

1317333

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

11

Small-scale

0.479

High

1317392

LN28A
Protein lin-28 homolog A

1

1

Small-scale

0.479

High

1317410

MTA1
Metastasis-associated protein MTA1

1

13

Small-scale

0.479

High

1341466

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

4

Small-scale

0.479

High

1362207

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

6

Small-scale

0.479

High

1424085

CDYL2
Chromodomain Y-like protein 2

1

10

Small-scale

0.479

High

1490123

CDYL
Chromodomain Y-like protein

1

17

Small-scale

0.479

High

1491905

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.479

High

1317383

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

0

Small-scale

0.458

High

1408777

RTF2
Replication termination factor 2

1

0

Small-scale

0.458

High

1440820

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

Small-scale

0.458

High

1053225

Q05BA5
Nuclear receptor coactivator

1

3

High-throughput

0.457

High

778021

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.445

High

1297209

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.437

High

378401

IFNB
Interferon beta

1

0

Small-scale

0.249

Low

378663

IL2RA
Interleukin-2 receptor subunit alpha

1

0

Small-scale

0.249

Low

1282962

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

Small-scale

0.249

Low

1341453

SUMF1
Formylglycine-generating enzyme

1

0

Small-scale

0.249

Low

1423716

DENR
Density-regulated protein

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025