HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: TRPS1 (Q9UHF7)
Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79)
Gene: TRPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1912 Hs			1 1281
+	Hs
		1018736 CHD3_HUMAN (23-1905): 0: 1595: 66.89		TRPS1_HUMAN (1-1281): 0: 1888: 100.00
+	Hs
		1033642 CHD4_HUMAN (1-1912): 0: 1719: 100.00		IKZF1_HUMAN (781-1272): 5.18e-107: 349: 19.45
+	Hs
		1059934 CHD4_HUMAN (1-1912): 0: 1719: 100.00		IKZF2_HUMAN (800-1270): 2.98e-84: 287: 16.20
+	Hs
		1059935 CHD4_HUMAN (1-1912): 0: 1719: 100.00		IKZF3_HUMAN (850-1268): 4.38e-82: 280: 18.63
+	Hs
		1059868 CHD4_HUMAN (1-1912): 0: 1719: 100.00		IKZF4_HUMAN (771-1268): 1.19e-79: 276: 18.47
+	Hs
		1018462 CHD3_HUMAN (23-1905): 0: 1595: 66.89		IKZF1_HUMAN (781-1272): 5.18e-107: 349: 19.45
+	Hs
		798897 CHD4_HUMAN (1-1912): 0: 1719: 100.00		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		1018744 CHD3_HUMAN (23-1905): 0: 1595: 66.89		IKZF3_HUMAN (850-1268): 4.38e-82: 280: 18.63
+	Mm
		570297 CHD4_MOUSE (1-1900): 0: 1680: 97.80		GATA1_MOUSE (804-1033): 5.18e-40: 155: 20.21
+	Hs
		799024 CHD7_HUMAN (3-1678): 0: 805: 23.02		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		229335 SMCA5_HUMAN (578-1624): 0: 791: 26.01		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		1332087 CHD8_HUMAN (489-1678): 0: 752: 28.31		IKZF5_HUMAN (909-1270): 9.35e-58: 207: 17.46
+	Mm
		570299 SMCA5_MOUSE (601-1624): 0: 795: 26.39		GATA1_MOUSE (804-1033): 5.18e-40: 155: 20.21
+	Hs
		658639 SMCA1_HUMAN (617-1597): 0: 779: 27.44		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		620584 CHD7_HUMAN (3-1678): 0: 805: 23.02		GATA3_HUMAN (870-1017): 3.94e-36: 144: 27.03
+	Mm
		140046 Q8BR71_MOUSE (52-682): 0: 654: 57.77		IKZF3_MOUSE (783-1268): 4.76e-82: 280: 17.04
+	Hs
		620435 CHD7_HUMAN (3-1678): 0: 805: 23.02		GATA2_HUMAN (821-1072): 2.62e-27: 119: 20.60
+	Hs
		799010 CHD8_HUMAN (489-1678): 0: 752: 28.31		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		151387 CHD1_HUMAN (491-1733): 0: 734: 27.99		GATA4_HUMAN (870-1060): 3.74e-45: 171: 28.36
+	Hs
		620390 CHD6_HUMAN (279-1685): 0: 782: 24.76		GATA2_HUMAN (821-1072): 2.62e-27: 119: 20.60