HitPredict

Interactor 1: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	34079125, 22665060
Identification Methods	proximity labelling technology, pull down, anti bait coimmunoprecipitation, far western blotting
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0045296 - cadherin binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 1190
+	Hs
		282374 NEBL_HUMAN (36-261): 8.63e-29: 116: 31.67		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1126376 SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1314994 SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		282324 NEBL_HUMAN (36-261): 8.63e-29: 116: 31.67		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		990840 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Mm
		761854 SRC8_MOUSE (59-260): 8.14e-23: 99.2: 21.68		ZO1_MOUSE (19-1176): 3.53e-128: 433: 36.40
+	Hs
		990858 SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		159209 ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Hs
		942401 BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1142986 PACN1_MOUSE (7-261): 1.63e-24: 103: 19.48		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143395 BAIP2_MOUSE (19-261): 3.01e-24: 102: 15.35		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143327 SH3G2_MOUSE (47-261): 9.83e-23: 97.2: 17.21		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Rn
		1144017 BAIP2_RAT (19-261): 3.69e-24: 102: 15.35		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Mm
		1143413 SH3R3_MOUSE (158-259): 6.67e-13: 70.3: 24.27		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Dm
		1363696 Q9VDF4_DROME (102-261): 1.79e-26: 109: 24.59		Q9VHK4_DROME (24-347): 4.82e-23: 108: 21.17
+	Dm
		331926 O96046_DROME (69-261): 7.44e-29: 116: 22.69		Q7K4E2_DROME (17-121): 7.61e-13: 75.2: 23.59
+	Hs
		1052264 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Rn
		1144080 BAIP2_RAT (19-261): 3.69e-24: 102: 15.35		DLG3_RAT (372-595): 5.53e-13: 75.5: 18.10
+	Hs
		235554 VINEX_HUMAN (181-260): 1.77e-09: 59.6: 25.30		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77