Protein: PUF4
Pumilio homology domain family member 4

Gene: PUF4
Organism: Saccharomyces cerevisiae S288C
Interactions: 59
UniProt ID: P25339

Gene Ontology (top 5):
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0003729 - mRNA binding
GO:0005737 - cytoplasm
GO:0008104 - intracellular protein localization
GO:0010608 - post-transcriptional regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

523152

HSP71
Heat shock protein SSA1

3

10

High-throughput

0.633

High

672102

POP2
Poly(A) ribonuclease POP2

2

9

Small-scale

0.595

High

672088

PUF4
Pumilio homology domain family member 4

1

7

High-throughput

0.590

High

526000

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

672089

SRO9
RNA-binding protein SRO9

1

6

High-throughput

0.541

High

672090

NOT1
General negative regulator of transcription subunit 1

1

5

High-throughput

0.541

High

672096

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

12

High-throughput

0.541

High

672098

WHI3
Protein WHI3

1

1

High-throughput

0.541

High

672099

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.541

High

672104

DHH1
ATP-dependent RNA helicase DHH1

1

11

High-throughput

0.541

High

672105

LSM4
LSM complex subunit LSM4

1

1

High-throughput

0.541

High

672117

CAF40
Protein CAF40

1

5

High-throughput

0.541

High

672093

XPO1
Exportin-1

1

8

High-throughput

0.536

High

666394

DBP2
ATP-dependent RNA helicase DBP2

1

2

High-throughput

0.515

High

672095

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

2

High-throughput

0.515

High

672125

SLK19
Kinetochore protein SLK19

1

1

High-throughput

0.515

High

441049

KAPA
cAMP-dependent protein kinase type 1

1

2

High-throughput

0.501

High

517909

SSBP1
Single-stranded nucleic acid-binding protein

1

11

High-throughput

0.501

High

602332

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

672113

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

1

High-throughput

0.501

High

672112

3HAO
3-hydroxyanthranilate 3,4-dioxygenase

1

0

High-throughput

0.493

High

672115

PALF
pH-response regulator protein palF/RIM8

1

0

High-throughput

0.493

High

672123

RAD34
DNA repair protein RAD34

1

0

High-throughput

0.493

High

672124

TSR2
Pre-rRNA-processing protein TSR2

1

0

High-throughput

0.493

High

672116

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.486

High

558598

CAF20
Cap-associated protein CAF20

1

2

Small-scale

0.479

High

672094

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

4

Small-scale

0.479

High

672097

SMY2
Protein SMY2

1

4

High-throughput

0.479

High

672119

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

672129

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

672131

CMR1
DNA damage-binding protein CMR1

1

4

High-throughput

0.479

High

672100

SWD2
COMPASS component SWD2

1

3

High-throughput

0.470

High

672101

NCB5R
NADH-cytochrome b5 reductase 1

1

1

High-throughput

0.470

High

672109

PFS2
Polyadenylation factor subunit 2

1

4

High-throughput

0.470

High

364942

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.445

High

386581

TBB
Tubulin beta chain

1

1

High-throughput

0.445

High

453439

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

486050

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.445

High

543919

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

672106

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

672108

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

672092

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

672110

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.437

High

672118

H3
Histone H3

1

6

High-throughput

0.437

High

672120

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.437

High

672121

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

672126

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

672130

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.437

High

672103

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

488363

HO
Homothallic switching endonuclease

1

1

Small-scale

0.407

High

672107

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

484266

KEX1
Pheromone-processing carboxypeptidase KEX1

1

0

High-throughput

0.269

Low

672091

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.269

Low

672111

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.269

Low

672114

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.269

Low

672122

PEX30
Peroxisomal membrane protein PEX30

1

0

Small-scale

0.249

Low

672127

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

672128

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025