HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: GFI1B (Q5VTD9)
Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)
Gene: GFI1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	16713569
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 330
+	Hs
		1047835 TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50		GFI1B_HUMAN (1-330): 5.91e-118: 345: 100.00
+	Hs
		1047997 TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50		GFI1B_HUMAN (1-330): 5.91e-118: 345: 100.00
+	Hs
		1061777 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		ZN383_HUMAN (94-330): 3.1e-113: 338: 34.29
+	Hs
		49561 TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59		FEZF1_HUMAN (151-328): 3.27e-43: 156: 46.67
+	Hs
		1061770 TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00		ZNF34_HUMAN (4-143): 1.58e-09: 61: 11.54
+	Ce
		111687 UNC37_CAEEL (18-160): 8.47e-43: 153: 28.47		GFI1H_CAEEL (244-322): 1.45e-11: 66.2: 36.71