Protein: TLE4
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)

Gene: TLE4
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q04727

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1047798

TLE1
Transducin-like enhancer protein 1

5

18

Small-scale

0.912

High

1047891

TLE2
Transducin-like enhancer protein 2

4

18

High-throughput

0.892

High

1048151

TLE5
TLE family member 5

4

16

High-throughput

0.886

High

1047951

TLE3
Transducin-like enhancer protein 3

3

18

High-throughput

0.847

High

1006984

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.694

High

1048184

TBX20
T-box transcription factor TBX20

3

20

High-throughput

0.656

High

330132

VENTX
Homeobox protein VENTX

3

20

High-throughput

0.650

High

1037712

PAX5
Paired box protein Pax-5

2

20

Small-scale

0.636

High

1048149

HME1
Homeobox protein engrailed-1

2

20

High-throughput

0.628

High

162549

ANM5
Protein arginine N-methyltransferase 5

1

5

Small-scale

0.618

High

1048177

MEP50
Methylosome protein WDR77

1

17

Small-scale

0.618

High

1048178

KPCD2
Serine/threonine-protein kinase D2

1

15

High-throughput

0.618

High

1048179

DDX21
Nucleolar RNA helicase 2

1

15

High-throughput

0.618

High

877772

TNNI2
Troponin I, fast skeletal muscle

2

3

High-throughput

0.611

High

1048152

RIPP1
Protein ripply1

2

19

High-throughput

0.611

High

1048157

HLX
H2.0-like homeobox protein

2

20

High-throughput

0.611

High

1048161

ISX
Intestine-specific homeobox

2

20

High-throughput

0.611

High

1048165

RIPP2
Protein ripply2

2

19

High-throughput

0.611

High

1048168

ARMC8
Armadillo repeat-containing protein 8

2

7

High-throughput

0.611

High

789095

NUP62
Nuclear pore glycoprotein p62

2

14

High-throughput

0.606

High

1048173

HES6
Transcription cofactor HES-6

2

20

High-throughput

0.601

High

1048164

CC183
Coiled-coil domain-containing protein 183

3

6

High-throughput

0.599

High

478906

PO2F2
POU domain, class 2, transcription factor 2

1

18

Small-scale

0.561

High

814791

CUX1
Homeobox protein cut-like 1

1

20

Small-scale

0.561

High

1048172

ZMY19
Zinc finger MYND domain-containing protein 19

2

1

High-throughput

0.558

High

1048162

EIPR1
EARP and GARP complex-interacting protein 1

1

17

High-throughput

0.553

High

1048166

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1048169

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.553

High

1048175

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.553

High

799021

BRCA1
Breast cancer type 1 susceptibility protein

1

18

High-throughput

0.552

High

892670

DNLI4
DNA ligase 4

1

1

High-throughput

0.552

High

935718

MFAP4
Microfibril-associated glycoprotein 4

2

7

High-throughput

0.549

High

49561

FEZF1
Fez family zinc finger protein 1

1

1

High-throughput

0.536

High

337926

SIX6
Homeobox protein SIX6

1

20

High-throughput

0.536

High

927246

ATX1
Ataxin-1

1

7

High-throughput

0.536

High

943470

DSCR6
Protein ripply3

1

19

High-throughput

0.536

High

1048167

MAEA
E3 ubiquitin-protein transferase MAEA

1

3

High-throughput

0.536

High

1048176

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

1048181

UBIP1
Upstream-binding protein 1

1

5

High-throughput

0.536

High

384400

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.501

High

1006351

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.501

High

346972

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.489

High

142955

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

181502

TBXT
T-box transcription factor T

1

20

High-throughput

0.479

High

662217

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

662407

GATA2
Endothelial transcription factor GATA-2

1

20

High-throughput

0.479

High

224984

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

226539

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

289140

PRDM1
PR domain zinc finger protein 1

1

6

High-throughput

0.479

High

473934

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

519968

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

612992

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

685164

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

725246

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

938438

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

942431

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

1048150

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

1048153

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1048154

FOXI1
Forkhead box protein I1

1

20

High-throughput

0.479

High

1048155

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.479

High

1048156

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

1048160

TBR1
T-box brain protein 1

1

20

High-throughput

0.479

High

1048170

SP7
Transcription factor Sp7

1

16

High-throughput

0.479

High

1048171

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

1048174

FEV
Protein FEV

1

18

High-throughput

0.479

High

1048182

VSX1
Visual system homeobox 1

1

20

High-throughput

0.479

High

1048183

MKLN1
Muskelin

1

11

High-throughput

0.479

High

1048185

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

290921

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.458

High

529673

TAU
Microtubule-associated protein tau

1

19

High-throughput

0.445

High

1048163

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

High-throughput

0.445

High

1048158

EEA1
Early endosome antigen 1

1

19

High-throughput

0.437

High

1048159

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

3

High-throughput

0.437

High

1048180

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

261158

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

298848

LYZL6
Lysozyme-like protein 6

1

1

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025