HitPredict

Interactor 1: EMC2 (Q15006)
ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)
Gene: EMC2

Interactor 2: EMC1 (Q8N766)
ER membrane protein complex subunit 1
Gene: EMC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	22119785, 27342126, 35271311, 26186194, 26496610, 28514442, 33961781, 32439656
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0034975 - protein folding in endoplasmic reticulum GO:0045050 - protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0071816 - tail-anchored membrane protein insertion into ER membrane GO:0072546 - EMC complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 993
+	Hs
		1173494 TMTC3_HUMAN (102-296): 1.43e-23: 102: 11.96		EMC1_HUMAN (1-993): 0: 1483: 100.00
+	Dm
		1364840 Q9VEQ2_DROME (6-272): 1.49e-59: 193: 45.69		Q9VHY6_DROME (20-993): 0: 759: 32.66