HitPredict

Interactor 1: SYK (Q15046)
Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)
Gene: KARS1

Interactor 2: SYK (Q15046)
Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)
Gene: KARS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.872

The method score is based on:

Property Details
Experiments 18272479, 21536907, 24212136
Identification Methods x-ray crystallography, molecular sieving, classical fluorescence spectroscopy, x ray scattering
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains tRNA-synt_2~tRNA-synt_2, tRNA_anti-codon~tRNA-synt_2, tRNA_anti-codon~tRNA_anti-codon
Common GO terms GO:0000049 - tRNA binding
GO:0002276 - basophil activation involved in immune response
GO:0002863 - positive regulation of inflammatory response to antigenic stimulus
GO:0003877 - ATP:ADP adenylyltransferase activity
GO:0004824 - lysine-tRNA ligase activity
and 17 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 597
Hs

1 597
+ Mm
+ Zm
+ Hs
+ Ec
+ Ec
+ Ec
+ Cj
+ Sc
+ Sc
+ Hs
+ Sc
+ Sc
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024