HitPredict

Interactor 1: PSB4 (P22141)
Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11)
Gene: PRE1

Interactor 2: RPN12 (P32496)
26S proteasome regulatory subunit RPN12 (Nuclear integrity protein 1)
Gene: RPN12

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	11029046, 11805826, 15242647, 17916559, 19412159, 20061387, 21878652, 16429126, 37968396
Identification Methods	coimmunoprecipitation, tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 198 Sc			1 274
+	Hs
		819778 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27
+	Sc
		675398 PSB5_YEAST (2-197): 4.88e-65: 203: 22.45		RPN12_YEAST (1-274): 3.71e-102: 300: 100.00
+	Hs
		637645 PSA2_HUMAN (4-198): 2.88e-64: 199: 20.31		PSMD8_HUMAN (16-274): 3.08e-101: 300: 31.27
+	Sc
		691462 PSB1_YEAST (3-192): 1e-57: 182: 22.63		RPN12_YEAST (1-274): 3.71e-102: 300: 100.00
+	Sc
		625918 PSB2_YEAST (3-185): 5.08e-55: 177: 21.86		RPN12_YEAST (1-274): 3.71e-102: 300: 100.00
+	Sp
		840107 PSA5_SCHPO (3-196): 7.67e-64: 199: 20.20		RPN12_SCHPO (11-274): 3.43e-91: 272: 30.91
+	Dm
		1178954 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		Q9V436_DROME (1-274): 2.47e-78: 239: 26.72