Protein: HMGB3
High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)

Gene: HMGB3
Organism: Homo sapiens
Interactions: 68
UniProt ID: O15347

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186611

HMGB1
High mobility group protein B1

4

16

High-throughput

0.881

High

186621

HMGB2
High mobility group protein B2

3

16

High-throughput

0.827

High

140060

SDCB1
Syntenin-1

4

6

High-throughput

0.698

High

186642

H31
Histone H3.1

3

20

High-throughput

0.640

High

186620

PAX6
Paired box protein Pax-6

2

12

High-throughput

0.606

High

186628

MEOX1
Homeobox protein MOX-1

2

20

High-throughput

0.606

High

186601

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

186665

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.573

High

186641

RAC1
Ras-related C3 botulinum toxin substrate 1

2

5

High-throughput

0.571

High

186647

PAX5
Paired box protein Pax-5

2

9

High-throughput

0.553

High

186613

TAU
Microtubule-associated protein tau

2

19

High-throughput

0.552

High

186615

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

Small-scale

0.550

High

186605

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

186656

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.536

High

186654

Q6FHY5
MEOX2 protein

1

19

High-throughput

0.515

High

186618

CP2B6
Cytochrome P450 2B6

1

0

High-throughput

0.493

High

186623

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.489

High

186643

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

186629

MEOX2
Homeobox protein MOX-2

1

20

High-throughput

0.481

High

186664

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

5

High-throughput

0.481

High

186603

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

186606

CYTN
Cystatin-SN

1

1

Small-scale

0.479

High

186607

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

High-throughput

0.479

High

186608

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

186609

ANXA6
Annexin A6

1

8

High-throughput

0.479

High

186610

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

186612

PARP1
Poly [ADP-ribose] polymerase 1

1

15

High-throughput

0.479

High

186614

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

186616

CEBPB
CCAAT/enhancer-binding protein beta

1

13

High-throughput

0.479

High

186617

LMNB1
Lamin-B1

1

12

High-throughput

0.479

High

186619

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

9

High-throughput

0.479

High

186622

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

186624

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.479

High

186630

LHX2
LIM/homeobox protein Lhx2

1

14

High-throughput

0.479

High

186631

CDK9
Cyclin-dependent kinase 9

1

15

High-throughput

0.479

High

186632

MECP2
Methyl-CpG-binding protein 2

1

14

High-throughput

0.479

High

186634

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.479

High

186635

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

186636

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

186637

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

186638

RS4X
Small ribosomal subunit protein eS4, X isoform

1

5

High-throughput

0.479

High

186639

H4
Histone H4

1

8

High-throughput

0.479

High

186640

H2B1C
Histone H2B type 1-C/E/F/G/I

1

15

High-throughput

0.479

High

186644

H33
Histone H3.3

1

20

High-throughput

0.479

High

186645

TFAP4
Transcription factor AP-4

1

4

Small-scale

0.479

High

186646

EWS
RNA-binding protein EWS

1

13

High-throughput

0.479

High

186648

CBX3
Chromobox protein homolog 3

1

17

High-throughput

0.479

High

186649

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.479

High

186650

RBM39
RNA-binding protein 39

1

12

High-throughput

0.479

High

186651

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

186652

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

1

High-throughput

0.479

High

186653

LARP7
La-related protein 7

1

19

High-throughput

0.479

High

186655

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

186657

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

186658

CGAS
Cyclic GMP-AMP synthase

1

4

Small-scale

0.479

High

186660

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

186662

FEV
Protein FEV

1

14

High-throughput

0.479

High

186666

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

186667

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

186661

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

186663

ZDHC5
Palmitoyltransferase ZDHHC5

1

7

High-throughput

0.445

High

186602

RHBT1
Rho-related BTB domain-containing protein 1

1

13

High-throughput

0.437

High

186604

RASL1
RasGAP-activating-like protein 1

1

3

High-throughput

0.437

High

186625

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

186626

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.437

High

186633

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.437

High

186659

ASB11
Ankyrin repeat and SOCS box protein 11

1

14

High-throughput

0.437

High

186627

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.408

High


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Last updated: 11Aug2025